Vanadium-catalyzed oxidative Strecker reaction: α-C-H cyanation of para-methoxyphenyl (PMP)-protected primary amines

Chuo Chen, Chen Zhu, Ji Bao Xia

Research output: Contribution to journalArticle

20 Scopus citations


We describe an oxidative Strecker reaction that allows for direct cyanation of para-methoxyphenyl (PMP)-protected primary amines. A vanadium(V) complex was used as the catalyst and TBHP as the oxidant. The cyanation occurs at the α-C position bearing either an alkyl or an aromatic group. This method provides a direct access to α-aminonitrile from amines with one-carbon extension.

Original languageEnglish (US)
Pages (from-to)232-234
Number of pages3
JournalTetrahedron Letters
Issue number1
StatePublished - Jan 1 2014



  • C-H cyanation
  • Oxidative Strecker reaction
  • Primary amine
  • Schiff base ligand
  • Vanadium catalyst

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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