Vancomycin resistance in Staphylococci

Arjun Srinivasan, James D. Dick, Trish M. Perl

Research output: Contribution to journalReview article

175 Citations (Scopus)

Abstract

Vancomycin resistance has been reported in clinical isolates of both coagulase-negative staphylococci and Staphylococcus aureus. The emerging threat of widespread vancomycin resistance poses a serious public health concern given the fact that vancomycin has long been the preferred treatment of antibiotic-resistant gram-positive organisms. Though major efforts are now being focused on improving our understanding of vancomycin resistance, there is much that remains unknown at this time. This article reviews the major epidemiologic, microbiologic, and clinical characteristics of vancomycin resistance in both coagulase-negative staphylococci and S. aureus. The review begins with a discussion of issues common to both coagulase-negative staphylococci and S. aureus, such as definitions, laboratory detection of vancomycin resistance, and infection control issues related to vancomycin-resistant staphylococci. The rest of the article is then devoted to a discussion of issues unique to each organism, including epidemiology, risk factors for infection, mechanisms of resistance, and management options.

Original languageEnglish (US)
Pages (from-to)430-438
Number of pages9
JournalClinical Microbiology Reviews
Volume15
Issue number3
DOIs
StatePublished - Jul 23 2002

Fingerprint

Vancomycin Resistance
Staphylococcus
Coagulase
Staphylococcus aureus
Vancomycin
Infection Control
Epidemiology
Public Health
Anti-Bacterial Agents
Infection

ASJC Scopus subject areas

  • Epidemiology
  • Immunology and Microbiology(all)
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Vancomycin resistance in Staphylococci. / Srinivasan, Arjun; Dick, James D.; Perl, Trish M.

In: Clinical Microbiology Reviews, Vol. 15, No. 3, 23.07.2002, p. 430-438.

Research output: Contribution to journalReview article

Srinivasan, Arjun ; Dick, James D. ; Perl, Trish M. / Vancomycin resistance in Staphylococci. In: Clinical Microbiology Reviews. 2002 ; Vol. 15, No. 3. pp. 430-438.
@article{4e4326a6117c4133a4308771f9ec8947,
title = "Vancomycin resistance in Staphylococci",
abstract = "Vancomycin resistance has been reported in clinical isolates of both coagulase-negative staphylococci and Staphylococcus aureus. The emerging threat of widespread vancomycin resistance poses a serious public health concern given the fact that vancomycin has long been the preferred treatment of antibiotic-resistant gram-positive organisms. Though major efforts are now being focused on improving our understanding of vancomycin resistance, there is much that remains unknown at this time. This article reviews the major epidemiologic, microbiologic, and clinical characteristics of vancomycin resistance in both coagulase-negative staphylococci and S. aureus. The review begins with a discussion of issues common to both coagulase-negative staphylococci and S. aureus, such as definitions, laboratory detection of vancomycin resistance, and infection control issues related to vancomycin-resistant staphylococci. The rest of the article is then devoted to a discussion of issues unique to each organism, including epidemiology, risk factors for infection, mechanisms of resistance, and management options.",
author = "Arjun Srinivasan and Dick, {James D.} and Perl, {Trish M.}",
year = "2002",
month = "7",
day = "23",
doi = "10.1128/CMR.15.3.430-438.2002",
language = "English (US)",
volume = "15",
pages = "430--438",
journal = "Clinical Microbiology Reviews",
issn = "0893-8512",
publisher = "American Society for Microbiology",
number = "3",

}

TY - JOUR

T1 - Vancomycin resistance in Staphylococci

AU - Srinivasan, Arjun

AU - Dick, James D.

AU - Perl, Trish M.

PY - 2002/7/23

Y1 - 2002/7/23

N2 - Vancomycin resistance has been reported in clinical isolates of both coagulase-negative staphylococci and Staphylococcus aureus. The emerging threat of widespread vancomycin resistance poses a serious public health concern given the fact that vancomycin has long been the preferred treatment of antibiotic-resistant gram-positive organisms. Though major efforts are now being focused on improving our understanding of vancomycin resistance, there is much that remains unknown at this time. This article reviews the major epidemiologic, microbiologic, and clinical characteristics of vancomycin resistance in both coagulase-negative staphylococci and S. aureus. The review begins with a discussion of issues common to both coagulase-negative staphylococci and S. aureus, such as definitions, laboratory detection of vancomycin resistance, and infection control issues related to vancomycin-resistant staphylococci. The rest of the article is then devoted to a discussion of issues unique to each organism, including epidemiology, risk factors for infection, mechanisms of resistance, and management options.

AB - Vancomycin resistance has been reported in clinical isolates of both coagulase-negative staphylococci and Staphylococcus aureus. The emerging threat of widespread vancomycin resistance poses a serious public health concern given the fact that vancomycin has long been the preferred treatment of antibiotic-resistant gram-positive organisms. Though major efforts are now being focused on improving our understanding of vancomycin resistance, there is much that remains unknown at this time. This article reviews the major epidemiologic, microbiologic, and clinical characteristics of vancomycin resistance in both coagulase-negative staphylococci and S. aureus. The review begins with a discussion of issues common to both coagulase-negative staphylococci and S. aureus, such as definitions, laboratory detection of vancomycin resistance, and infection control issues related to vancomycin-resistant staphylococci. The rest of the article is then devoted to a discussion of issues unique to each organism, including epidemiology, risk factors for infection, mechanisms of resistance, and management options.

UR - http://www.scopus.com/inward/record.url?scp=0036310636&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036310636&partnerID=8YFLogxK

U2 - 10.1128/CMR.15.3.430-438.2002

DO - 10.1128/CMR.15.3.430-438.2002

M3 - Review article

VL - 15

SP - 430

EP - 438

JO - Clinical Microbiology Reviews

JF - Clinical Microbiology Reviews

SN - 0893-8512

IS - 3

ER -