TY - JOUR
T1 - Variability in antibiotic duration for necrotizing enterocolitis and outcomes in a large multicenter cohort
AU - Children’s Hospitals Neonatal Consortium NEC Focus Group
AU - Ahmad, Irfan
AU - Premkumar, Muralidhar H.
AU - Hair, Amy B.
AU - Sullivan, Kevin M.
AU - Zaniletti, Isabella
AU - Sharma, Jotishna
AU - Nayak, Sujir Pritha
AU - Reber, Kristina M.
AU - Padula, Michael
AU - Brozanski, Beverly
AU - DiGeronimo, Robert
AU - Yanowitz, Toby Debra
AU - Ahmad, Irfan
AU - Premkumar, Muralidhar H.
AU - Hair, Amy B.
AU - Sharma, Jotishna
AU - Nayak, Sujir Pritha
AU - Reber, Kristina M.
AU - Padula, Michael
AU - Brozanski, Beverly
AU - DiGeronimo, Robert
AU - Yanowitz, Toby Debra
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2022/11
Y1 - 2022/11
N2 - Objectives: To evaluate variability in antibiotic duration for necrotizing enterocolitis (NEC) and associated clinical outcomes. Study design: Five-hundred ninety-one infants with NEC (315 medical; 276 surgical) were included from 22 centers participating in Children’s Hospitals Neonatal Consortium (CHNC). Multivariable analyses were used to determine predictors of variability in time to full feeds (TFF) and length of stay (LOS). Results: Median (IQR) antibiotic duration was 12 (9, 17) days for medical and 17 (14, 21) days for surgical NEC. Wide variability in antibiotic use existed both within and among centers. Duration of antibiotic therapy was associated with longer TFF in both medical (OR 1.04, 95% CI [1.01, 1.05], p < 0.001) and surgical NEC (OR 1.02 [1, 1.03] p = 0.046); and with longer LOS in medical (OR 1.03 [1.02, 1.04], p < 0.001) and surgical NEC (OR 1.01 [1.01, 1.02], p = 0.002). Conclusion: Antibiotic duration for both medical and surgical NEC remains variable within and among high level NICUs.
AB - Objectives: To evaluate variability in antibiotic duration for necrotizing enterocolitis (NEC) and associated clinical outcomes. Study design: Five-hundred ninety-one infants with NEC (315 medical; 276 surgical) were included from 22 centers participating in Children’s Hospitals Neonatal Consortium (CHNC). Multivariable analyses were used to determine predictors of variability in time to full feeds (TFF) and length of stay (LOS). Results: Median (IQR) antibiotic duration was 12 (9, 17) days for medical and 17 (14, 21) days for surgical NEC. Wide variability in antibiotic use existed both within and among centers. Duration of antibiotic therapy was associated with longer TFF in both medical (OR 1.04, 95% CI [1.01, 1.05], p < 0.001) and surgical NEC (OR 1.02 [1, 1.03] p = 0.046); and with longer LOS in medical (OR 1.03 [1.02, 1.04], p < 0.001) and surgical NEC (OR 1.01 [1.01, 1.02], p = 0.002). Conclusion: Antibiotic duration for both medical and surgical NEC remains variable within and among high level NICUs.
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U2 - 10.1038/s41372-022-01433-2
DO - 10.1038/s41372-022-01433-2
M3 - Article
C2 - 35760891
AN - SCOPUS:85133796492
SN - 0743-8346
VL - 42
SP - 1458
EP - 1464
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 11
ER -