Abstract
Cytomegalovirus (CMV) infection after pediatric lung transplantation is a significant risk factor for morbidity and mortality in the first year after transplantation. Multiple strategies have been reported for CMV prevention among adult lung transplant programs. In contrast, little information has been reported regarding protocols for prevention and detection of CMV from pediatric programs. We conducted a survey to better understand the range of practice patterns for CMV prevention and detection at pediatric lung transplant centers. A self-administered questionnaire was distributed to 11 pediatric lung transplant centers identified through the International Pediatric Lung Transplant Collaborative in September 2002. A member of the lung transplant team from each institution was asked to provide the methods of CMV prevention and surveillance. Eight of 11 centers surveyed responded to the questionnaire accounting for 45.6% (26 of 57) and 100% (three of three) of the pediatric lung transplants performed in the US and UK in 2001, respectively. All centers used prophylactic therapy against CMV with either ganciclovir or valganciclovir with duration ranging from 3.5 wk to indefinitely. Most centers (six of eight) prescribed a prophylactic regimen based on donor and recipient CMV serostatus. Half (four of eight) of the centers report using CMV hyperimmune globulin in addition to an antiviral agent. Method for CMV detection varied widely, including use of conventional viral culture (n = 1), antigenemia (n = 7), and polymerase chain reaction (n = 2). A wide range of strategies is used to prevent and detect CMV in pediatric lung transplant recipients with little empiric evidence demonstrating the optimal approach. A retrospective analysis among these centers is being conducted to evaluate the efficacy of these approaches.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 469-473 |
| Number of pages | 5 |
| Journal | Pediatric Transplantation |
| Volume | 7 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2003 |
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Keywords
- Cytomegalovirus
- Lung transplantation
- Pediatrics
- Standard care
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Transplantation
Cite this
Variability in standard care for cytomegalovirus prevention and detection in pediatric lung transplantation : Survey of eight pediatric lung transplant programs. / Danziger-Isakov, Lara A.; Faro, Albert; Sweet, Stuart; Michaels, Marian G.; Aurora, Paul; Mogayzel, Peter J.; Mallory, George B.; Boyer, Debra M.; Rice, Tom B.; DelaMorena, Maite; DeBaun, Michael R.
In: Pediatric Transplantation, Vol. 7, No. 6, 12.2003, p. 469-473.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Variability in standard care for cytomegalovirus prevention and detection in pediatric lung transplantation
T2 - Survey of eight pediatric lung transplant programs
AU - Danziger-Isakov, Lara A.
AU - Faro, Albert
AU - Sweet, Stuart
AU - Michaels, Marian G.
AU - Aurora, Paul
AU - Mogayzel, Peter J.
AU - Mallory, George B.
AU - Boyer, Debra M.
AU - Rice, Tom B.
AU - DelaMorena, Maite
AU - DeBaun, Michael R.
PY - 2003/12
Y1 - 2003/12
N2 - Cytomegalovirus (CMV) infection after pediatric lung transplantation is a significant risk factor for morbidity and mortality in the first year after transplantation. Multiple strategies have been reported for CMV prevention among adult lung transplant programs. In contrast, little information has been reported regarding protocols for prevention and detection of CMV from pediatric programs. We conducted a survey to better understand the range of practice patterns for CMV prevention and detection at pediatric lung transplant centers. A self-administered questionnaire was distributed to 11 pediatric lung transplant centers identified through the International Pediatric Lung Transplant Collaborative in September 2002. A member of the lung transplant team from each institution was asked to provide the methods of CMV prevention and surveillance. Eight of 11 centers surveyed responded to the questionnaire accounting for 45.6% (26 of 57) and 100% (three of three) of the pediatric lung transplants performed in the US and UK in 2001, respectively. All centers used prophylactic therapy against CMV with either ganciclovir or valganciclovir with duration ranging from 3.5 wk to indefinitely. Most centers (six of eight) prescribed a prophylactic regimen based on donor and recipient CMV serostatus. Half (four of eight) of the centers report using CMV hyperimmune globulin in addition to an antiviral agent. Method for CMV detection varied widely, including use of conventional viral culture (n = 1), antigenemia (n = 7), and polymerase chain reaction (n = 2). A wide range of strategies is used to prevent and detect CMV in pediatric lung transplant recipients with little empiric evidence demonstrating the optimal approach. A retrospective analysis among these centers is being conducted to evaluate the efficacy of these approaches.
AB - Cytomegalovirus (CMV) infection after pediatric lung transplantation is a significant risk factor for morbidity and mortality in the first year after transplantation. Multiple strategies have been reported for CMV prevention among adult lung transplant programs. In contrast, little information has been reported regarding protocols for prevention and detection of CMV from pediatric programs. We conducted a survey to better understand the range of practice patterns for CMV prevention and detection at pediatric lung transplant centers. A self-administered questionnaire was distributed to 11 pediatric lung transplant centers identified through the International Pediatric Lung Transplant Collaborative in September 2002. A member of the lung transplant team from each institution was asked to provide the methods of CMV prevention and surveillance. Eight of 11 centers surveyed responded to the questionnaire accounting for 45.6% (26 of 57) and 100% (three of three) of the pediatric lung transplants performed in the US and UK in 2001, respectively. All centers used prophylactic therapy against CMV with either ganciclovir or valganciclovir with duration ranging from 3.5 wk to indefinitely. Most centers (six of eight) prescribed a prophylactic regimen based on donor and recipient CMV serostatus. Half (four of eight) of the centers report using CMV hyperimmune globulin in addition to an antiviral agent. Method for CMV detection varied widely, including use of conventional viral culture (n = 1), antigenemia (n = 7), and polymerase chain reaction (n = 2). A wide range of strategies is used to prevent and detect CMV in pediatric lung transplant recipients with little empiric evidence demonstrating the optimal approach. A retrospective analysis among these centers is being conducted to evaluate the efficacy of these approaches.
KW - Cytomegalovirus
KW - Lung transplantation
KW - Pediatrics
KW - Standard care
UR - http://www.scopus.com/inward/record.url?scp=10744221566&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10744221566&partnerID=8YFLogxK
U2 - 10.1046/j.1397-3142.2003.00102.x
DO - 10.1046/j.1397-3142.2003.00102.x
M3 - Article
C2 - 14870896
AN - SCOPUS:10744221566
VL - 7
SP - 469
EP - 473
JO - Pediatric Transplantation
JF - Pediatric Transplantation
SN - 1397-3142
IS - 6
ER -