Variability of hepatitis E serologic assays in a pediatric liver transplant recipient: Challenges to diagnosing hepatitis E virus infection in the United States

P. K. Sue, N. Pisanic, C. D. Heaney, T. Mixson-Hayden, S. Kamili, K. Nelson, K. B. Schwarz, M. Forman, A. Valsamakis, J. Ticehurst, W. Karnsakul

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Hepatitis E virus (HEV) is an emerging cause of viral hepatitis among immunocompromised individuals in developed countries. Yet the diagnosis of HEV infection in the United States remains challenging, because of the variable sensitivity and specificity of currently available tests, and the lack of a US Food and Drug Administration-approved test. We report a case of multiple discordant HEV serology results in a pediatric liver transplant recipient with idiopathic hepatitis, and review the challenges to diagnosis of HEV infection in the United States.

Original languageEnglish (US)
Pages (from-to)284-288
Number of pages5
JournalTransplant Infectious Disease
Volume17
Issue number2
DOIs
StatePublished - Jan 1 2015

Fingerprint

Hepatitis E
Hepatitis E virus
Virus Diseases
Pediatrics
Liver
Hepatitis
Serology
United States Food and Drug Administration
Developed Countries
Sensitivity and Specificity
Transplant Recipients

Keywords

  • Hepatitis E virus
  • Liver transplantation
  • Viral diagnostics

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

Variability of hepatitis E serologic assays in a pediatric liver transplant recipient : Challenges to diagnosing hepatitis E virus infection in the United States. / Sue, P. K.; Pisanic, N.; Heaney, C. D.; Mixson-Hayden, T.; Kamili, S.; Nelson, K.; Schwarz, K. B.; Forman, M.; Valsamakis, A.; Ticehurst, J.; Karnsakul, W.

In: Transplant Infectious Disease, Vol. 17, No. 2, 01.01.2015, p. 284-288.

Research output: Contribution to journalArticle

Sue, PK, Pisanic, N, Heaney, CD, Mixson-Hayden, T, Kamili, S, Nelson, K, Schwarz, KB, Forman, M, Valsamakis, A, Ticehurst, J & Karnsakul, W 2015, 'Variability of hepatitis E serologic assays in a pediatric liver transplant recipient: Challenges to diagnosing hepatitis E virus infection in the United States', Transplant Infectious Disease, vol. 17, no. 2, pp. 284-288. https://doi.org/10.1111/tid.12366
Sue, P. K. ; Pisanic, N. ; Heaney, C. D. ; Mixson-Hayden, T. ; Kamili, S. ; Nelson, K. ; Schwarz, K. B. ; Forman, M. ; Valsamakis, A. ; Ticehurst, J. ; Karnsakul, W. / Variability of hepatitis E serologic assays in a pediatric liver transplant recipient : Challenges to diagnosing hepatitis E virus infection in the United States. In: Transplant Infectious Disease. 2015 ; Vol. 17, No. 2. pp. 284-288.
@article{0a0730e2ee5a4528945b001447b8cc6e,
title = "Variability of hepatitis E serologic assays in a pediatric liver transplant recipient: Challenges to diagnosing hepatitis E virus infection in the United States",
abstract = "Hepatitis E virus (HEV) is an emerging cause of viral hepatitis among immunocompromised individuals in developed countries. Yet the diagnosis of HEV infection in the United States remains challenging, because of the variable sensitivity and specificity of currently available tests, and the lack of a US Food and Drug Administration-approved test. We report a case of multiple discordant HEV serology results in a pediatric liver transplant recipient with idiopathic hepatitis, and review the challenges to diagnosis of HEV infection in the United States.",
keywords = "Hepatitis E virus, Liver transplantation, Viral diagnostics",
author = "Sue, {P. K.} and N. Pisanic and Heaney, {C. D.} and T. Mixson-Hayden and S. Kamili and K. Nelson and Schwarz, {K. B.} and M. Forman and A. Valsamakis and J. Ticehurst and W. Karnsakul",
year = "2015",
month = "1",
day = "1",
doi = "10.1111/tid.12366",
language = "English (US)",
volume = "17",
pages = "284--288",
journal = "Transplant Infectious Disease",
issn = "1398-2273",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Variability of hepatitis E serologic assays in a pediatric liver transplant recipient

T2 - Challenges to diagnosing hepatitis E virus infection in the United States

AU - Sue, P. K.

AU - Pisanic, N.

AU - Heaney, C. D.

AU - Mixson-Hayden, T.

AU - Kamili, S.

AU - Nelson, K.

AU - Schwarz, K. B.

AU - Forman, M.

AU - Valsamakis, A.

AU - Ticehurst, J.

AU - Karnsakul, W.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Hepatitis E virus (HEV) is an emerging cause of viral hepatitis among immunocompromised individuals in developed countries. Yet the diagnosis of HEV infection in the United States remains challenging, because of the variable sensitivity and specificity of currently available tests, and the lack of a US Food and Drug Administration-approved test. We report a case of multiple discordant HEV serology results in a pediatric liver transplant recipient with idiopathic hepatitis, and review the challenges to diagnosis of HEV infection in the United States.

AB - Hepatitis E virus (HEV) is an emerging cause of viral hepatitis among immunocompromised individuals in developed countries. Yet the diagnosis of HEV infection in the United States remains challenging, because of the variable sensitivity and specificity of currently available tests, and the lack of a US Food and Drug Administration-approved test. We report a case of multiple discordant HEV serology results in a pediatric liver transplant recipient with idiopathic hepatitis, and review the challenges to diagnosis of HEV infection in the United States.

KW - Hepatitis E virus

KW - Liver transplantation

KW - Viral diagnostics

UR - http://www.scopus.com/inward/record.url?scp=84925345118&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925345118&partnerID=8YFLogxK

U2 - 10.1111/tid.12366

DO - 10.1111/tid.12366

M3 - Article

C2 - 25648626

AN - SCOPUS:84925345118

VL - 17

SP - 284

EP - 288

JO - Transplant Infectious Disease

JF - Transplant Infectious Disease

SN - 1398-2273

IS - 2

ER -