Variability of hepatitis E serologic assays in a pediatric liver transplant recipient: Challenges to diagnosing hepatitis E virus infection in the United States

P. K. Sue, N. Pisanic, C. D. Heaney, T. Mixson-Hayden, S. Kamili, K. Nelson, K. B. Schwarz, M. Forman, A. Valsamakis, J. Ticehurst, W. Karnsakul

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Hepatitis E virus (HEV) is an emerging cause of viral hepatitis among immunocompromised individuals in developed countries. Yet the diagnosis of HEV infection in the United States remains challenging, because of the variable sensitivity and specificity of currently available tests, and the lack of a US Food and Drug Administration-approved test. We report a case of multiple discordant HEV serology results in a pediatric liver transplant recipient with idiopathic hepatitis, and review the challenges to diagnosis of HEV infection in the United States.

Original languageEnglish (US)
Pages (from-to)284-288
Number of pages5
JournalTransplant Infectious Disease
Volume17
Issue number2
DOIs
StatePublished - Apr 1 2015

Keywords

  • Hepatitis E virus
  • Liver transplantation
  • Viral diagnostics

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation

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    Sue, P. K., Pisanic, N., Heaney, C. D., Mixson-Hayden, T., Kamili, S., Nelson, K., Schwarz, K. B., Forman, M., Valsamakis, A., Ticehurst, J., & Karnsakul, W. (2015). Variability of hepatitis E serologic assays in a pediatric liver transplant recipient: Challenges to diagnosing hepatitis E virus infection in the United States. Transplant Infectious Disease, 17(2), 284-288. https://doi.org/10.1111/tid.12366