Variants of Mta, the mouse maternally transmitted antigen, determined by three alleles of the extrachromosomal gene Mtf

K. Fischer Lindahl, B. Hausmann, J. L. Guenet

Research output: Contribution to journalArticle

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Abstract

Two new forms of Mta, the maternally transmitted antigen of the mouse, were defined by cytotoxic T lymphocytes. One is found in laboratory mice carrying the β allele of the maternally transmitted factor, Mtf, which were previously thought to be Mta-negative. The other is associated with a new allele, Mtf(γ), and is found in wild mice from Toulouse. Like the common form of Mta, determined by the extrachromosomal Mtf(α), the new forms are also dependent on the a allele of Hmt, a chromosomal gene linked to H-2, and are associated with β2-microglobulin. Killers could be raised in all six combinations of α, β, and γ mice, showing that each form of Mtf determines a distinct (set of) epitopes(s). We propose that the product of the Hmt gene, a class I MHC antigen, presents a peptide derived from a mitochondrial gene product on the cell surface and thereby creates the target antigen, Mta.

Original languageEnglish (US)
Pages (from-to)29-41
Number of pages13
JournalJournal of Immunogenetics
Volume17
Issue number1-2
StatePublished - 1990

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Alleles
Genes
Histocompatibility Antigens Class I
Mitochondrial Genes
Cytotoxic T-Lymphocytes
Epitopes
Antigens
Peptides
Mouse Mta antigen

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Variants of Mta, the mouse maternally transmitted antigen, determined by three alleles of the extrachromosomal gene Mtf. / Fischer Lindahl, K.; Hausmann, B.; Guenet, J. L.

In: Journal of Immunogenetics, Vol. 17, No. 1-2, 1990, p. 29-41.

Research output: Contribution to journalArticle

Fischer Lindahl, K. ; Hausmann, B. ; Guenet, J. L. / Variants of Mta, the mouse maternally transmitted antigen, determined by three alleles of the extrachromosomal gene Mtf. In: Journal of Immunogenetics. 1990 ; Vol. 17, No. 1-2. pp. 29-41.
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