VARIANTS OF Mta, THE MOUSE MATERNALLY TRANSMITTED ANTIGEN, DETERMINED BY THREE ALLELES OF THE EXTRACHROMOSOMAL GENE Mtf

K. Fischer Lindahl, B. Hausmann, J. L. Guenet

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Two new forms of Mta, the maternally transmitted antigen of the mouse, were defined by cytotoxic T lymphocytes. One is found in laboratory mice carrying the β allele of the maternally transmitted factor, Mtf, which were previously thought to be Mta‐negative. The other is associated with a new allele, Mtfγ, and is found in wild mice from Toulouse. Like the common form of Mta, determined by the extrachromosomal Mrfα, the new forms are also dependent on the α allele of Hmt, a chromosomal gene linked to H‐2. and are associated with β2‐microglobulin. Killers could be raised in all six combinations of a, β, and γ mice, showing that each form of Mtf determines a distinct (set of) epitope(s). We propose that the product of the Hmt gene, a class I MHC antigen, presents a peptide derived from a mitochondrial gene product on the cell surface and thereby creates the target antigen, Mta.

Original languageEnglish (US)
Pages (from-to)29-41
Number of pages13
JournalInternational Journal of Immunogenetics
Volume17
Issue number1-2
DOIs
StatePublished - Feb 1990

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'VARIANTS OF Mta, THE MOUSE MATERNALLY TRANSMITTED ANTIGEN, DETERMINED BY THREE ALLELES OF THE EXTRACHROMOSOMAL GENE Mtf'. Together they form a unique fingerprint.

  • Cite this