Variation in hepatic bile composition following cholecystectomy in patients with previous gallstones

J. L. Boyer, J. R. Bloomer, W. C. Maddrey, D. Tilson

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Abstract

The composition of fasting hepatic bile was analyzed in 63 samples from 8 patients following cholecystectomy to determine if bile was lithogenic in patients with previous cholesterol gallstones after removal of the gallbladder. Bile specimens were obtained from t tubes over a 7-20 day study period following re establishment of the enterohepatic circulation. Bile composition varied on a day to day basis in each patient. 18 of 63 samples were lithogenic according to criteria of Admirand and Small while 35 of 63 samples were lithogenic according to criteria of Hegardt and Dam. Variations in the composition of hepatic bile appeared related to changes in the excretion rate of bile acids. These studies demonstrate that hepatic bile may be lithogenic after cholecystectomy and indicate that factors other than sequestration of the bile acid pool in the gallbladder influence the enterohepatic circulation of bile acids and the lithogenicity of bile.

Original languageEnglish (US)
Pages (from-to)211-217
Number of pages7
JournalYale Journal of Biology and Medicine
Volume47
Issue number4
StatePublished - 1974

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Cholecystectomy
Gallstones
Bile Acids and Salts
Bile
Liver
Chemical analysis
Enterohepatic Circulation
Gallbladder
Cholesterol
Fasting

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Variation in hepatic bile composition following cholecystectomy in patients with previous gallstones. / Boyer, J. L.; Bloomer, J. R.; Maddrey, W. C.; Tilson, D.

In: Yale Journal of Biology and Medicine, Vol. 47, No. 4, 1974, p. 211-217.

Research output: Contribution to journalArticle

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