Variation in placental type 2 11β-hydroxysteroid dehydrogenase activity is not related to birth weight or placental weight

Fraser M. Rogerson; Kathleen M. Kayes; Perrin C. White

doi:10.1016/S0303-7207(97)04027-6

Variation in placental type 2 11β-hydroxysteroid dehydrogenase activity is not related to birth weight or placental weight

Fraser M. Rogerson, Kathleen M. Kayes, Perrin C. White

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

It has been suggested that the association between the development of hypertension and a combination of low birth weight and high placental weight can be explained by variations in expression of NAD⁺-dependent 11β-hydroxysteroid dehydrogenase (11-HSD2 or 11-HSD K) in the placenta. Enzymatic activity and mRNA levels of 11-HSD2 were measured in 111 human placentas taken from normal births. There were no correlations between either 11-HSD2 activity or mRNA levels and either fetal or placental weight. These studies suggest that variations in placental 11-HSD activity do not influence fetal or placental weight in humans.

Original language	English (US)
Pages (from-to)	103-109
Number of pages	7
Journal	Molecular and Cellular Endocrinology
Volume	128
Issue number	1-2
DOIs	https://doi.org/10.1016/S0303-7207(97)04027-6
State	Published - Apr 4 1997

Keywords

Glucocorticoid
Hypertension
Placenta
Regulation

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology

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10.1016/S0303-7207(97)04027-6

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title = "Variation in placental type 2 11β-hydroxysteroid dehydrogenase activity is not related to birth weight or placental weight",

abstract = "It has been suggested that the association between the development of hypertension and a combination of low birth weight and high placental weight can be explained by variations in expression of NAD+-dependent 11β-hydroxysteroid dehydrogenase (11-HSD2 or 11-HSD K) in the placenta. Enzymatic activity and mRNA levels of 11-HSD2 were measured in 111 human placentas taken from normal births. There were no correlations between either 11-HSD2 activity or mRNA levels and either fetal or placental weight. These studies suggest that variations in placental 11-HSD activity do not influence fetal or placental weight in humans.",

keywords = "Glucocorticoid, Hypertension, Placenta, Regulation",

author = "Rogerson, {Fraser M.} and Kayes, {Kathleen M.} and White, {Perrin C.}",

note = "Funding Information: We are grateful for the assistance of the staff of the East maternity ward at Parkland Hospital. This work was supported by grant DK42169 from the National Institutes of Health.",

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AU - Rogerson, Fraser M.

AU - Kayes, Kathleen M.

AU - White, Perrin C.

N1 - Funding Information: We are grateful for the assistance of the staff of the East maternity ward at Parkland Hospital. This work was supported by grant DK42169 from the National Institutes of Health.

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N2 - It has been suggested that the association between the development of hypertension and a combination of low birth weight and high placental weight can be explained by variations in expression of NAD+-dependent 11β-hydroxysteroid dehydrogenase (11-HSD2 or 11-HSD K) in the placenta. Enzymatic activity and mRNA levels of 11-HSD2 were measured in 111 human placentas taken from normal births. There were no correlations between either 11-HSD2 activity or mRNA levels and either fetal or placental weight. These studies suggest that variations in placental 11-HSD activity do not influence fetal or placental weight in humans.

AB - It has been suggested that the association between the development of hypertension and a combination of low birth weight and high placental weight can be explained by variations in expression of NAD+-dependent 11β-hydroxysteroid dehydrogenase (11-HSD2 or 11-HSD K) in the placenta. Enzymatic activity and mRNA levels of 11-HSD2 were measured in 111 human placentas taken from normal births. There were no correlations between either 11-HSD2 activity or mRNA levels and either fetal or placental weight. These studies suggest that variations in placental 11-HSD activity do not influence fetal or placental weight in humans.

KW - Glucocorticoid

KW - Hypertension

KW - Placenta

KW - Regulation

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Variation in placental type 2 11β-hydroxysteroid dehydrogenase activity is not related to birth weight or placental weight

Abstract

Keywords

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