Variation in placental type 2 11β-hydroxysteroid dehydrogenase activity is not related to birth weight or placental weight

Fraser M. Rogerson, Kathleen M. Kayes, Perrin C. White

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

It has been suggested that the association between the development of hypertension and a combination of low birth weight and high placental weight can be explained by variations in expression of NAD+-dependent 11β-hydroxysteroid dehydrogenase (11-HSD2 or 11-HSD K) in the placenta. Enzymatic activity and mRNA levels of 11-HSD2 were measured in 111 human placentas taken from normal births. There were no correlations between either 11-HSD2 activity or mRNA levels and either fetal or placental weight. These studies suggest that variations in placental 11-HSD activity do not influence fetal or placental weight in humans.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalMolecular and Cellular Endocrinology
Volume128
Issue number1-2
DOIs
StatePublished - Apr 4 1997

Keywords

  • Glucocorticoid
  • Hypertension
  • Placenta
  • Regulation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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