TY - JOUR
T1 - Variations in hemoglobin measurement and eligibility criteria across blood donation services are associated with differing low-hemoglobin deferral rates
T2 - a BEST Collaborative study
AU - BEST Collaborative Study Group
AU - Zalpuri, Saurabh
AU - Romeijn, Bas
AU - Allara, Elias
AU - Goldman, Mindy
AU - Kamel, Hany
AU - Gorlin, Jed
AU - Vassallo, Ralph
AU - Grégoire, Yves
AU - Goto, Naoko
AU - Flanagan, Peter
AU - Speedy, Joanna
AU - Buser, Andreas
AU - Kutner, Jose Mauro
AU - Magnussen, Karin
AU - Castrén, Johanna
AU - Culler, Liz
AU - Sussmann, Harry
AU - Prinsze, Femmeke J.
AU - Belanger, Kevin
AU - Compernolle, Veerle
AU - Tiberghien, Pierre
AU - Cardenas, Jose Manuel
AU - Gandhi, Manish J.
AU - West, Kamille A.
AU - Lee, Cheuk Kwong
AU - James, Sian
AU - Wells, Deanne
AU - Sutor, Laurie J.
AU - Wendel, Silvano
AU - Coleman, Matthew
AU - Seltsam, Axel
AU - Roden, Kimberly
AU - Steele, Whitney R.
AU - Bohonek, Milos
AU - Alcantara, Ramir
AU - Di Angelantonio, Emanuele
AU - van den Hurk, Katja
N1 - Publisher Copyright:
© 2020 AABB
PY - 2020/3/1
Y1 - 2020/3/1
N2 - BACKGROUND: Determination of blood donor hemoglobin (Hb) levels is a pre-requisite to ensure donor safety and blood product quality. We aimed to identify Hb measurement practices across blood donation services and to what extent differences associate with low-Hb deferral rates. METHODS: An online survey was performed among Biomedical Excellence for Safer Transfusion (BEST) Collaborative members, extended with published data. Multivariable negative-binomial regression models were built to estimate adjusted associations of minimum donation intervals, Hb cut-offs (high, ≥13.5 g/dL in men or ≥ 12.5 g/dL in women, vs. lower values), iron monitoring (yes/no), providing or prescribing iron supplementation (yes/no), post-versus pre-donation Hb measurement and geographical location (Asian vs. rest), with low-Hb deferral rates. RESULTS: Data were included from 38 blood services. Low-Hb deferral rates varied from 0.11% to 8.81% among men and 0.84% to 31.85% among women. Services with longer minimum donation intervals had significantly lower deferral rates among both women (rate ratio, RR 0.53, 95%CI 0.33-0.84) and men (RR 0.53, 95%CI 0.31-0.90). In women, iron supplementation was associated with lower Hb deferral rates (RR 0.47, 95%CI 0.23-0.94). Finally, being located in Asia was associated with higher low-Hb deferral rates; RR 9.10 (95%CI 3.89-21.27) for women and 6.76 (95%CI 2.45-18.68) for men. CONCLUSION: Differences in Hb measurement and eligibility criteria, particularly longer donation intervals and iron supplementation in women, are associated with variations in low-Hb deferral rates. These insights could help improve both blood donation service efficiency and donor care.
AB - BACKGROUND: Determination of blood donor hemoglobin (Hb) levels is a pre-requisite to ensure donor safety and blood product quality. We aimed to identify Hb measurement practices across blood donation services and to what extent differences associate with low-Hb deferral rates. METHODS: An online survey was performed among Biomedical Excellence for Safer Transfusion (BEST) Collaborative members, extended with published data. Multivariable negative-binomial regression models were built to estimate adjusted associations of minimum donation intervals, Hb cut-offs (high, ≥13.5 g/dL in men or ≥ 12.5 g/dL in women, vs. lower values), iron monitoring (yes/no), providing or prescribing iron supplementation (yes/no), post-versus pre-donation Hb measurement and geographical location (Asian vs. rest), with low-Hb deferral rates. RESULTS: Data were included from 38 blood services. Low-Hb deferral rates varied from 0.11% to 8.81% among men and 0.84% to 31.85% among women. Services with longer minimum donation intervals had significantly lower deferral rates among both women (rate ratio, RR 0.53, 95%CI 0.33-0.84) and men (RR 0.53, 95%CI 0.31-0.90). In women, iron supplementation was associated with lower Hb deferral rates (RR 0.47, 95%CI 0.23-0.94). Finally, being located in Asia was associated with higher low-Hb deferral rates; RR 9.10 (95%CI 3.89-21.27) for women and 6.76 (95%CI 2.45-18.68) for men. CONCLUSION: Differences in Hb measurement and eligibility criteria, particularly longer donation intervals and iron supplementation in women, are associated with variations in low-Hb deferral rates. These insights could help improve both blood donation service efficiency and donor care.
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U2 - 10.1111/trf.15676
DO - 10.1111/trf.15676
M3 - Article
C2 - 32034925
AN - SCOPUS:85079218106
SN - 0041-1132
VL - 60
SP - 544
EP - 552
JO - Transfusion
JF - Transfusion
IS - 3
ER -