Variations in screening and management practices for subsequent asymptomatic meningiomas in childhood, adolescent and young adult cancer survivors

Lisanne C. Verbruggen, Melissa M. Hudson, Daniel C. Bowers, Cécile M. Ronckers, Gregory T. Armstrong, Roderick Skinner, Eelco W. Hoving, Geert O. Janssens, Helena J.H. van der Pal, Leontine C.M. Kremer, Renée L. Mulder

Research output: Contribution to journalArticle

Abstract

Introduction: Childhood, adolescent and young adult (CAYA) cancer survivors treated with cranial radiotherapy are at risk for developing subsequent meningiomas. There is insufficient evidence concerning the benefits and harms of screening for subsequent meningiomas, and uncertainty about the most appropriate clinical management of asymptomatic meningiomas. Data describing current clinical decision-making is essential to formulate surveillance recommendations. Methods: We created an online survey to identify the current international clinical practice regarding screening for and management of subsequent asymptomatic meningiomas among CAYA cancer survivors. Fifty-nine physicians from North America and Europe with expertise relevant to meningiomas were invited to participate. Results: Thirty-four physicians (58%) completed the survey. The reported number of CAYA cancer survivors that physicians are willing to screen to detect one meningioma varied widely from 0 to 750 (median 50). Physicians expressed concerns regarding harms from MRI screening, including risks of unnecessary interventions (n = 25, 73%) and overdiagnosis (n = 19, 56%). Growth pattern (n = 33, 97%), location (n = 31, 91%) and size (n = 29, 85%) were endorsed as the most important factors influencing the decision to treat asymptomatic meningiomas. A challenging location (n = 14, 52%), indolent tumor growth pattern (n = 13, 48%), and absence of symptoms (n = 12, 44%) were endorsed as the main reasons to monitor without intervention. Conclusions: There is international variation in opinions and clinical practice regarding screening for subsequent asymptomatic meningiomas among at risk CAYA cancer survivors. Decision-making regarding interventions of asymptomatic meningiomas are largely driven by clinical characteristics. These valuable insights into current clinical practice will inform surveillance guidelines for CAYA cancer survivors.

Original languageEnglish (US)
Pages (from-to)417-425
Number of pages9
JournalJournal of Neuro-Oncology
Volume147
Issue number2
DOIs
StatePublished - Apr 1 2020

Keywords

  • CAYA cancer survivors
  • Physician survey
  • Screening
  • Subsequent asymptomatic meningioma
  • Treatment

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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  • Cite this

    Verbruggen, L. C., Hudson, M. M., Bowers, D. C., Ronckers, C. M., Armstrong, G. T., Skinner, R., Hoving, E. W., Janssens, G. O., van der Pal, H. J. H., Kremer, L. C. M., & Mulder, R. L. (2020). Variations in screening and management practices for subsequent asymptomatic meningiomas in childhood, adolescent and young adult cancer survivors. Journal of Neuro-Oncology, 147(2), 417-425. https://doi.org/10.1007/s11060-020-03436-5