Varicella zoster virus encephalitis in solid organ transplant recipients: Case series and review of literature

Minji Kang, Saima Aslam

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Herpes zoster encephalitis (HZE) is a rare complication of varicella zoster virus (VZV) infection. We report two cases of HZE in solid organ transplant (SOT) recipients and review 10 other cases in the literature. In this review, rash was present in 67% of cases. Despite the absence of a rash, high clinical suspicion for HZE is necessary and empiric antiviral therapy should be considered. While with variable outcome, it was associated with high mortality rate of 42%. Prompt initiation of antiviral therapy remains crucial in decreasing morbidity and mortality from this fatal disease.

Original languageEnglish (US)
Article numbere13038
JournalTransplant Infectious Disease
Volume21
Issue number2
DOIs
StatePublished - Apr 2019
Externally publishedYes

Keywords

  • encephalitis
  • herpes zoster
  • solid organ transplant
  • varicella zoster virus

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation

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