Vascular disease and risk factors, rate of progression, and survival in Alzheimer's disease

Deepika Bhargava, Myron F. Weiner, Linda S. Hynan, Ramon Diaz-Arrastia, Anne M. Lipton

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Two hundred forty-seven patients with early Alzheimer's disease were studied for the association of demographic, functional, and cognitive status and vascular comorbidities and risk factors present at index visit to rate of clinical disease progression over 3 years and to survival time. Patients who progressed to the moderate stage were designated fast progressors; those who remained in the early stage were designated slow progressors. At index visit, Mini-Mental State Exam score was significantly lower for the fast than the slow group; global impairment was significantly higher for the fast group. Cognitive scores showed greater annual decline in the fast group, and the fast group also had a greater annualized global change. The fast group had a shorter median survival time from onset, but age at onset, age at initial visit, history of heart problems, myocardial infarct, stroke, hypertension, diabetes, or past or current smoking did not differ between groups.

Original languageEnglish (US)
Pages (from-to)78-82
Number of pages5
JournalJournal of Geriatric Psychiatry and Neurology
Volume19
Issue number2
DOIs
StatePublished - Jun 2006

Fingerprint

Vascular Diseases
Alzheimer Disease
Survival Rate
Survival
Age of Onset
Disease Progression
Comorbidity
Smoking
Stroke
Myocardial Infarction
Demography
Hypertension
vascular factor

Keywords

  • Alzheimer
  • Vascular comorbidity
  • Vascular risk factors

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology
  • Neuroscience(all)

Cite this

Vascular disease and risk factors, rate of progression, and survival in Alzheimer's disease. / Bhargava, Deepika; Weiner, Myron F.; Hynan, Linda S.; Diaz-Arrastia, Ramon; Lipton, Anne M.

In: Journal of Geriatric Psychiatry and Neurology, Vol. 19, No. 2, 06.2006, p. 78-82.

Research output: Contribution to journalArticle

Bhargava, Deepika ; Weiner, Myron F. ; Hynan, Linda S. ; Diaz-Arrastia, Ramon ; Lipton, Anne M. / Vascular disease and risk factors, rate of progression, and survival in Alzheimer's disease. In: Journal of Geriatric Psychiatry and Neurology. 2006 ; Vol. 19, No. 2. pp. 78-82.
@article{3ea13e60bb4f4fdfa2ec3a58ba3df90c,
title = "Vascular disease and risk factors, rate of progression, and survival in Alzheimer's disease",
abstract = "Two hundred forty-seven patients with early Alzheimer's disease were studied for the association of demographic, functional, and cognitive status and vascular comorbidities and risk factors present at index visit to rate of clinical disease progression over 3 years and to survival time. Patients who progressed to the moderate stage were designated fast progressors; those who remained in the early stage were designated slow progressors. At index visit, Mini-Mental State Exam score was significantly lower for the fast than the slow group; global impairment was significantly higher for the fast group. Cognitive scores showed greater annual decline in the fast group, and the fast group also had a greater annualized global change. The fast group had a shorter median survival time from onset, but age at onset, age at initial visit, history of heart problems, myocardial infarct, stroke, hypertension, diabetes, or past or current smoking did not differ between groups.",
keywords = "Alzheimer, Vascular comorbidity, Vascular risk factors",
author = "Deepika Bhargava and Weiner, {Myron F.} and Hynan, {Linda S.} and Ramon Diaz-Arrastia and Lipton, {Anne M.}",
year = "2006",
month = "6",
doi = "10.1177/0891988706286505",
language = "English (US)",
volume = "19",
pages = "78--82",
journal = "Journal of Geriatric Psychiatry and Neurology",
issn = "0891-9887",
publisher = "SAGE Publications Inc.",
number = "2",

}

TY - JOUR

T1 - Vascular disease and risk factors, rate of progression, and survival in Alzheimer's disease

AU - Bhargava, Deepika

AU - Weiner, Myron F.

AU - Hynan, Linda S.

AU - Diaz-Arrastia, Ramon

AU - Lipton, Anne M.

PY - 2006/6

Y1 - 2006/6

N2 - Two hundred forty-seven patients with early Alzheimer's disease were studied for the association of demographic, functional, and cognitive status and vascular comorbidities and risk factors present at index visit to rate of clinical disease progression over 3 years and to survival time. Patients who progressed to the moderate stage were designated fast progressors; those who remained in the early stage were designated slow progressors. At index visit, Mini-Mental State Exam score was significantly lower for the fast than the slow group; global impairment was significantly higher for the fast group. Cognitive scores showed greater annual decline in the fast group, and the fast group also had a greater annualized global change. The fast group had a shorter median survival time from onset, but age at onset, age at initial visit, history of heart problems, myocardial infarct, stroke, hypertension, diabetes, or past or current smoking did not differ between groups.

AB - Two hundred forty-seven patients with early Alzheimer's disease were studied for the association of demographic, functional, and cognitive status and vascular comorbidities and risk factors present at index visit to rate of clinical disease progression over 3 years and to survival time. Patients who progressed to the moderate stage were designated fast progressors; those who remained in the early stage were designated slow progressors. At index visit, Mini-Mental State Exam score was significantly lower for the fast than the slow group; global impairment was significantly higher for the fast group. Cognitive scores showed greater annual decline in the fast group, and the fast group also had a greater annualized global change. The fast group had a shorter median survival time from onset, but age at onset, age at initial visit, history of heart problems, myocardial infarct, stroke, hypertension, diabetes, or past or current smoking did not differ between groups.

KW - Alzheimer

KW - Vascular comorbidity

KW - Vascular risk factors

UR - http://www.scopus.com/inward/record.url?scp=33646595017&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646595017&partnerID=8YFLogxK

U2 - 10.1177/0891988706286505

DO - 10.1177/0891988706286505

M3 - Article

C2 - 16690992

AN - SCOPUS:33646595017

VL - 19

SP - 78

EP - 82

JO - Journal of Geriatric Psychiatry and Neurology

JF - Journal of Geriatric Psychiatry and Neurology

SN - 0891-9887

IS - 2

ER -