Vascular Disease and the Skeleton

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This chapter briefly relates the vital interplay between vascular biology and bone physiology as relevant to metabolic bone disease. It reviews data that highlight how prevalent vascular disease processes impair skeletal homeostatic mechanisms. Avascular necrosis (AVN), or osteonecrosis, represents the best-recognized clinical disorder of vascular disease and the skeleton. Demer, Tintut, and colleagues recently demonstrated that multiple oxylipids derived from LDL-a key contributor to atherosclerosis and arteriosclerosis-suppresses osteoblastmediated bone formation, enhances T-cell receptor activator of nuclear factor-kappa B ligand (RANKL) production, and impairs skeletal anabolic responses to PTH. The perspectives of experts in endocrinology, cardiology, developmental biology, orthopedics, biochemistry, genetics, pathology, engineering and hematology often emphasize different features of the relationship between the vasculature and bone. This integrated picture provides a "toolbox" for devising novel strategies to address unmet needs in skeletal health.

Original languageEnglish (US)
Title of host publicationPrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
Subtitle of host publicationEighth Edition
PublisherWiley Blackwell
Pages1012-1017
Number of pages6
ISBN (Electronic)9781118453926
ISBN (Print)9781118453889
DOIs
StatePublished - Jul 19 2013

Fingerprint

Vascular Diseases
Skeleton
Bone
RANK Ligand
Bone and Bones
Developmental Biology
Genetic Engineering
Osteonecrosis
Arteriosclerosis
Metabolic Bone Diseases
Endocrinology
Hematology
T-Cell Antigen Receptor
Cardiology
Osteogenesis
Biochemistry
Orthopedics
Blood Vessels
Atherosclerosis
Necrosis

Keywords

  • Arteriosclerosis
  • Atherosclerosis
  • Avascular necrosis (AVN)
  • Skeleton
  • Vascular disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Towler, D. A. (2013). Vascular Disease and the Skeleton. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition (pp. 1012-1017). Wiley Blackwell. https://doi.org/10.1002/9781118453926.ch121

Vascular Disease and the Skeleton. / Towler, Dwight A.

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition. Wiley Blackwell, 2013. p. 1012-1017.

Research output: Chapter in Book/Report/Conference proceedingChapter

Towler, DA 2013, Vascular Disease and the Skeleton. in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition. Wiley Blackwell, pp. 1012-1017. https://doi.org/10.1002/9781118453926.ch121
Towler DA. Vascular Disease and the Skeleton. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition. Wiley Blackwell. 2013. p. 1012-1017 https://doi.org/10.1002/9781118453926.ch121
Towler, Dwight A. / Vascular Disease and the Skeleton. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition. Wiley Blackwell, 2013. pp. 1012-1017
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