Vascular effects of rapid-acting insulin analogs in the diabetic patient: A review

Steve Fordan, Philip Raskin

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

The insulin analogs lispro, aspart, and glulisine are the only commercially available rapid-acting insulins to treat diabetes. We review the evidence for treating hyperglycemia, using insulin, and specifically using rapid-acting analogs in diabetic individuals, on the prevention of vascular events. We review the beneficial effects of insulin on the vascular system, which include vasodilation and anti-inflammatory actions. The effects of treating hyperglycemia and intensive blood glucose control on vascular outcomes are reviewed.

Original languageEnglish (US)
Pages (from-to)225-231
Number of pages7
JournalVascular health and risk management
Volume5
StatePublished - Dec 1 2009

Keywords

  • Aspart
  • Glulisine
  • Lispro
  • Nitric oxide synthetase
  • Nuclear factor kappa B

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hematology
  • Public Health, Environmental and Occupational Health
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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