Vascular instruction of pancreas development

Ondine Cleaver, Yuval Dor

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations

Abstract

Blood vessels course through organs, providing them with essential nutrient and gaseous exchange. However, the vasculature has also been shown to provide non-nutritional signals that play key roles in the control of organ growth, morphogenesis and homeostasis. Here, we examine a decade of work on the contribution of vascular paracrine signals to developing tissues, with a focus on pancreatic β-cells. During the early stages of embryonic development, blood vessels are required for pancreas specification. Later, the vasculature constrains pancreas branching, differentiation and growth. During adult life, capillaries provide a vascular niche for the maintenance of β-cell function and survival. We explore the possibility that the vasculature constitutes a dynamic and regionalized signaling system that carries out multiple and changing functions as it coordinately grows with the pancreatic epithelial tree.

Original languageEnglish (US)
Pages (from-to)2833-2843
Number of pages11
JournalDevelopment (Cambridge)
Volume139
Issue number16
DOIs
StatePublished - Aug 15 2012

Keywords

  • Endothelial
  • Islet
  • Pancreatic epithelium
  • Signaling
  • Vascular niche
  • β-cell

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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