Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein

Mark Henkemeyer, Derrick J. Rossi, Douglas P. Holmyard, Mira C. Puri, Geraldine Mbamalu, Kendraprasad Harpal, T. Shane Shih, Tyler Jacks, Tony Pawson

Research output: Contribution to journalArticle

271 Citations (Scopus)

Abstract

The gene encoding p120-rasGAP, a negative regulator of Ras, has been disrupted in mice. This Gap mutation affects the ability of endothelial cells to organize into a highly vascularized network and results in extensive neuronal cell death. Mutations in the Gap and Nfl genes have a synergistic effect, such that embryos homozygous for mutations in both genes show an exacerbated Gap phenotype. Thus rasGAP and neurofibromin act together to regulate Ras activity during embryonic development.

Original languageEnglish (US)
Pages (from-to)695-701
Number of pages7
JournalNature
Volume377
Issue number6551
StatePublished - 1995

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ras GTPase-Activating Proteins
Blood Vessels
Apoptosis
Mutation
Neurofibromin 1
Genes
Embryonic Development
Cell Death
Embryonic Structures
Endothelial Cells
Phenotype

ASJC Scopus subject areas

  • General

Cite this

Henkemeyer, M., Rossi, D. J., Holmyard, D. P., Puri, M. C., Mbamalu, G., Harpal, K., ... Pawson, T. (1995). Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein. Nature, 377(6551), 695-701.

Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein. / Henkemeyer, Mark; Rossi, Derrick J.; Holmyard, Douglas P.; Puri, Mira C.; Mbamalu, Geraldine; Harpal, Kendraprasad; Shih, T. Shane; Jacks, Tyler; Pawson, Tony.

In: Nature, Vol. 377, No. 6551, 1995, p. 695-701.

Research output: Contribution to journalArticle

Henkemeyer, M, Rossi, DJ, Holmyard, DP, Puri, MC, Mbamalu, G, Harpal, K, Shih, TS, Jacks, T & Pawson, T 1995, 'Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein', Nature, vol. 377, no. 6551, pp. 695-701.
Henkemeyer M, Rossi DJ, Holmyard DP, Puri MC, Mbamalu G, Harpal K et al. Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein. Nature. 1995;377(6551):695-701.
Henkemeyer, Mark ; Rossi, Derrick J. ; Holmyard, Douglas P. ; Puri, Mira C. ; Mbamalu, Geraldine ; Harpal, Kendraprasad ; Shih, T. Shane ; Jacks, Tyler ; Pawson, Tony. / Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein. In: Nature. 1995 ; Vol. 377, No. 6551. pp. 695-701.
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