Vascularizing organogenesis: Lessons from developmental biology and implications for regenerative medicine

Edward Daniel, Ondine Cleaver

Research output: Contribution to journalArticle

Abstract

Organogenesis requires tightly coordinated and patterned growth of numerous cell types to form a fully mature and vascularized organ. Endothelial cells (ECs) that line blood vessels develop alongside the growing organ, but only recently has their role in directing epithelial and stromal growth been appreciated. Endothelial, epithelial, and stromal cells in embryonic organs actively communicate with one another throughout development to ensure that the organ forms appropriately. What signals tell blood vessel progenitors where to go? How are tissues influenced by the vasculature that pervades it? In this chapter, we review the ways in which crosstalk between ECs and epithelial or stromal cells during development leads to a fully patterned pancreas, lung, or kidney. ECs in all of these organs are necessary for proper epithelial and stromal growth, but how they direct this process is organ- and time-specific, highlighting the concept of dynamic EC heterogeneity. We end with a discussion on how understanding cell-cell crosstalk during development can be applied therapeutically through the generation of transplantable miniature organ-like tissues called “organoids.” We will discuss the current state of organoid technology and highlight the major challenges in forming a properly patterned vascular network that will be critical in transforming them into a viable therapeutic option.

Original languageEnglish (US)
JournalCurrent Topics in Developmental Biology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Developmental Biology
Regenerative Medicine
Organogenesis
Endothelial Cells
Organoids
Blood Vessels
Stromal Cells
Growth
Epithelial Cells
Pancreas
Technology
Kidney
Cell Line
Lung

Keywords

  • Blood vessel
  • Endothelial cell heterogeneity
  • Endothelium
  • Kidney
  • Lung
  • Organogenesis
  • Organoids
  • Pancreas

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

@article{3383891447e14f39b71f9f5c8d5e2980,
title = "Vascularizing organogenesis: Lessons from developmental biology and implications for regenerative medicine",
abstract = "Organogenesis requires tightly coordinated and patterned growth of numerous cell types to form a fully mature and vascularized organ. Endothelial cells (ECs) that line blood vessels develop alongside the growing organ, but only recently has their role in directing epithelial and stromal growth been appreciated. Endothelial, epithelial, and stromal cells in embryonic organs actively communicate with one another throughout development to ensure that the organ forms appropriately. What signals tell blood vessel progenitors where to go? How are tissues influenced by the vasculature that pervades it? In this chapter, we review the ways in which crosstalk between ECs and epithelial or stromal cells during development leads to a fully patterned pancreas, lung, or kidney. ECs in all of these organs are necessary for proper epithelial and stromal growth, but how they direct this process is organ- and time-specific, highlighting the concept of dynamic EC heterogeneity. We end with a discussion on how understanding cell-cell crosstalk during development can be applied therapeutically through the generation of transplantable miniature organ-like tissues called “organoids.” We will discuss the current state of organoid technology and highlight the major challenges in forming a properly patterned vascular network that will be critical in transforming them into a viable therapeutic option.",
keywords = "Blood vessel, Endothelial cell heterogeneity, Endothelium, Kidney, Lung, Organogenesis, Organoids, Pancreas",
author = "Edward Daniel and Ondine Cleaver",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/bs.ctdb.2018.12.012",
language = "English (US)",
journal = "Current Topics in Developmental Biology",
issn = "0070-2153",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Vascularizing organogenesis

T2 - Lessons from developmental biology and implications for regenerative medicine

AU - Daniel, Edward

AU - Cleaver, Ondine

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Organogenesis requires tightly coordinated and patterned growth of numerous cell types to form a fully mature and vascularized organ. Endothelial cells (ECs) that line blood vessels develop alongside the growing organ, but only recently has their role in directing epithelial and stromal growth been appreciated. Endothelial, epithelial, and stromal cells in embryonic organs actively communicate with one another throughout development to ensure that the organ forms appropriately. What signals tell blood vessel progenitors where to go? How are tissues influenced by the vasculature that pervades it? In this chapter, we review the ways in which crosstalk between ECs and epithelial or stromal cells during development leads to a fully patterned pancreas, lung, or kidney. ECs in all of these organs are necessary for proper epithelial and stromal growth, but how they direct this process is organ- and time-specific, highlighting the concept of dynamic EC heterogeneity. We end with a discussion on how understanding cell-cell crosstalk during development can be applied therapeutically through the generation of transplantable miniature organ-like tissues called “organoids.” We will discuss the current state of organoid technology and highlight the major challenges in forming a properly patterned vascular network that will be critical in transforming them into a viable therapeutic option.

AB - Organogenesis requires tightly coordinated and patterned growth of numerous cell types to form a fully mature and vascularized organ. Endothelial cells (ECs) that line blood vessels develop alongside the growing organ, but only recently has their role in directing epithelial and stromal growth been appreciated. Endothelial, epithelial, and stromal cells in embryonic organs actively communicate with one another throughout development to ensure that the organ forms appropriately. What signals tell blood vessel progenitors where to go? How are tissues influenced by the vasculature that pervades it? In this chapter, we review the ways in which crosstalk between ECs and epithelial or stromal cells during development leads to a fully patterned pancreas, lung, or kidney. ECs in all of these organs are necessary for proper epithelial and stromal growth, but how they direct this process is organ- and time-specific, highlighting the concept of dynamic EC heterogeneity. We end with a discussion on how understanding cell-cell crosstalk during development can be applied therapeutically through the generation of transplantable miniature organ-like tissues called “organoids.” We will discuss the current state of organoid technology and highlight the major challenges in forming a properly patterned vascular network that will be critical in transforming them into a viable therapeutic option.

KW - Blood vessel

KW - Endothelial cell heterogeneity

KW - Endothelium

KW - Kidney

KW - Lung

KW - Organogenesis

KW - Organoids

KW - Pancreas

UR - http://www.scopus.com/inward/record.url?scp=85060074657&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060074657&partnerID=8YFLogxK

U2 - 10.1016/bs.ctdb.2018.12.012

DO - 10.1016/bs.ctdb.2018.12.012

M3 - Article

C2 - 30797509

AN - SCOPUS:85060074657

JO - Current Topics in Developmental Biology

JF - Current Topics in Developmental Biology

SN - 0070-2153

ER -