Vasoactive intestinal peptide (VIP) and VIP mRNA decrease in the cerebral cortex of nNOS knock-out(-/-) mice

Myeung Ju Kim, Kyeung Min Joo, Yoon Hee Chung, Yun Jung Lee, Jaehyup Kim, Bong Hee Lee, Dong Hoon Shin, Kyung Hoon Lee, Choong Ik Cha

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Although there is much evidence showing that NO regulates the release of VIP in several areas, there is no report about the influence of NO on VIP in the cerebral cortex. We therefore examined changes in VIP expression in the cerebral cortex of nNOS knock-out(-/-) mice using immunohistochemistry and in situ hybridization. The nNOS(-/-) mice had significantly fewer VIP-immunoreactive neurons than the control mice and the VIP mRNA as well as the VIP-immunoreactivity of the individual neuron was decreased in the nNOS(-/-) mice. The first demonstration of decrease in VIP expression in the cerebral cortex of nNOS(-/-) mice may provide useful data for investigating the relation between NO and VIP in the cerebral cortex and the mechanisms of many functions of these two neurotransmitters.

Original languageEnglish (US)
Pages (from-to)233-240
Number of pages8
JournalBrain Research
Volume978
Issue number1-2
DOIs
StatePublished - Jul 18 2003
Externally publishedYes

Keywords

  • Cerebral cortex
  • Neuronal nitric oxide synthase (nNOS) knock-out(-/-) mice
  • Nitric oxide (NO)
  • Vasoactive intestinal peptide (VIP)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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  • Cite this

    Kim, M. J., Joo, K. M., Chung, Y. H., Lee, Y. J., Kim, J., Lee, B. H., Shin, D. H., Lee, K. H., & Cha, C. I. (2003). Vasoactive intestinal peptide (VIP) and VIP mRNA decrease in the cerebral cortex of nNOS knock-out(-/-) mice. Brain Research, 978(1-2), 233-240. https://doi.org/10.1016/S0006-8993(03)02950-0