Vasoactive intestinal polypeptide: Release into hypophyseal portal blood

Sami I. Said, John C. Porter

Research output: Contribution to journalArticle

200 Scopus citations

Abstract

Immunoreactive vasoactive intestinal polypeptide (VIP) was present in portal hypophyseal blood of 24 male rats in concentrations (mean, 995 pg per ml) that were approximately 19 times as high as those in systemic arterial blood (mean, 52 pg per ml). The results demonstrate release of VIP from the hypothalamic-neurohypophyseal complex into the portal circulation, and establish a mechanism for direct influence of the peptide on pituitary function.

Original languageEnglish (US)
Pages (from-to)227-230
Number of pages4
JournalLife Sciences
Volume24
Issue number3
DOIs
StatePublished - Jan 15 1979

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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