Vasoactivity of arachidonic acid epoxides

Mairead A. Carroll, Michal Schwartzman, Jorge Capdevila, J. R. Falck, John C. McGiff

Research output: Contribution to journalArticle

110 Scopus citations

Abstract

Arachidonic acid (AA) can be metabolized to epoxides and their corresponding diols via the cytochrome P450 epoxygenase pathway. We have compared the vascular activity of four sythetically prepared epoxyeicosatrienoic acids, i.e. 5.6-, 8,9-, 11,12- and 14,15-EET (2-20 μM) on the isolated perfused rat tail artery. The 5,6-EET was equipotent with acetylcholine in dose dependently reducing vascular resistance (ED50 = 3.4 ± 0.5 μM). The 8,9-, 11,12- and 14,15-EETs of AA did not affect vascular resistance; neither did the 5,6-DHET and δ-lactone, hydrolysis products of 5,6-epoxide. We suggest that the 5,6-epoxide, in contrast to other cytochrome P450-derived products, contributes to the regulation of regional vascular tone.

Original languageEnglish (US)
Pages (from-to)281-283
Number of pages3
JournalEuropean Journal of Pharmacology
Volume138
Issue number2
DOIs
StatePublished - Jun 19 1987

Keywords

  • Arachidonic acid
  • Cytochrome P450
  • Epoxides
  • Vasodilatation

ASJC Scopus subject areas

  • Pharmacology

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    Carroll, M. A., Schwartzman, M., Capdevila, J., Falck, J. R., & McGiff, J. C. (1987). Vasoactivity of arachidonic acid epoxides. European Journal of Pharmacology, 138(2), 281-283. https://doi.org/10.1016/0014-2999(87)90445-6