Vasomotor sympathetic nerve responses to static handgrip after simulated microgravity.

A. Kamiya, D. Michikami, Qi Fu, S. Iwase, T. Mano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

During the isometric exercise, the autonomic nervous system has a major role in the regulation of arterial blood pressure, blood flow, and perfusion to the active skeletal muscle in humans. An increase in cardiac sympathetic nerve activity and a withdrawal of vagal tone cause elevations of heart rate, cardiac contractility and cardiac output. An increase in vasomotor sympathetic nerve activity causes a vascular constriction to redirect the oxygen transport to the contracting muscle. It has been reported that the autonomic and cardiovascular systems are commonly affected by the exposure to the real (i.e. spaceflight) and simulated microgravitational environment( i.e. 6 degrees head-down bed rest (HDBR)). The alteration in the autonomic system includes a reduced vagal tone, and an attenuated carotid-cardiac baroreflex function. It may also include an altered control of peripheral vessels, a reduced sympathetic vasoconstriction, an attenuated release of norepinephrine from sympathetic nerve terminal, an impaired myogenic contractility, an up- or down regulation of alpha-adrenergic receptors, and an attenuated multiple vasodilatation. Therefore, there seems to be a possibility that HDBR alters the sympathetic and cardiovascular responses to isometric exercise in humans, however, this possibility has not been examined efficiently. We compared the vasomotor sympathetic and cardiovascular responses to sustained handgrip (HG) until fatigue followed by post-exercise muscle ischemia (PEMI) after 14 days of HDBR, to those before HDBR, in 16 healthy males.

Original languageEnglish (US)
JournalJournal of gravitational physiology : a journal of the International Society for Gravitational Physiology
Volume6
Issue number1
StatePublished - 1999

Fingerprint

Weightlessness
Bed Rest
Head
Exercise
Receptors, Adrenergic, alpha
Space Flight
Muscles
Baroreflex
Autonomic Nervous System
Cardiovascular System
Vasoconstriction
Constriction
Vasodilation
Cardiac Output
Fatigue
Blood Vessels
Norepinephrine
Arterial Pressure
Skeletal Muscle
Up-Regulation

Cite this

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abstract = "During the isometric exercise, the autonomic nervous system has a major role in the regulation of arterial blood pressure, blood flow, and perfusion to the active skeletal muscle in humans. An increase in cardiac sympathetic nerve activity and a withdrawal of vagal tone cause elevations of heart rate, cardiac contractility and cardiac output. An increase in vasomotor sympathetic nerve activity causes a vascular constriction to redirect the oxygen transport to the contracting muscle. It has been reported that the autonomic and cardiovascular systems are commonly affected by the exposure to the real (i.e. spaceflight) and simulated microgravitational environment( i.e. 6 degrees head-down bed rest (HDBR)). The alteration in the autonomic system includes a reduced vagal tone, and an attenuated carotid-cardiac baroreflex function. It may also include an altered control of peripheral vessels, a reduced sympathetic vasoconstriction, an attenuated release of norepinephrine from sympathetic nerve terminal, an impaired myogenic contractility, an up- or down regulation of alpha-adrenergic receptors, and an attenuated multiple vasodilatation. Therefore, there seems to be a possibility that HDBR alters the sympathetic and cardiovascular responses to isometric exercise in humans, however, this possibility has not been examined efficiently. We compared the vasomotor sympathetic and cardiovascular responses to sustained handgrip (HG) until fatigue followed by post-exercise muscle ischemia (PEMI) after 14 days of HDBR, to those before HDBR, in 16 healthy males.",
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AU - Kamiya, A.

AU - Michikami, D.

AU - Fu, Qi

AU - Iwase, S.

AU - Mano, T.

PY - 1999

Y1 - 1999

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AB - During the isometric exercise, the autonomic nervous system has a major role in the regulation of arterial blood pressure, blood flow, and perfusion to the active skeletal muscle in humans. An increase in cardiac sympathetic nerve activity and a withdrawal of vagal tone cause elevations of heart rate, cardiac contractility and cardiac output. An increase in vasomotor sympathetic nerve activity causes a vascular constriction to redirect the oxygen transport to the contracting muscle. It has been reported that the autonomic and cardiovascular systems are commonly affected by the exposure to the real (i.e. spaceflight) and simulated microgravitational environment( i.e. 6 degrees head-down bed rest (HDBR)). The alteration in the autonomic system includes a reduced vagal tone, and an attenuated carotid-cardiac baroreflex function. It may also include an altered control of peripheral vessels, a reduced sympathetic vasoconstriction, an attenuated release of norepinephrine from sympathetic nerve terminal, an impaired myogenic contractility, an up- or down regulation of alpha-adrenergic receptors, and an attenuated multiple vasodilatation. Therefore, there seems to be a possibility that HDBR alters the sympathetic and cardiovascular responses to isometric exercise in humans, however, this possibility has not been examined efficiently. We compared the vasomotor sympathetic and cardiovascular responses to sustained handgrip (HG) until fatigue followed by post-exercise muscle ischemia (PEMI) after 14 days of HDBR, to those before HDBR, in 16 healthy males.

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