Venous Thromboembolism in Children with Sickle Cell Disease: A Retrospective Cohort Study

Gary M. Woods, Ruchika Sharma, Susan Creary, Sarah O'Brien, Joseph Stanek, Kan Hor, Jennifer Young, Amy L. Dunn, Riten Kumar

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Objectives: To describe the cumulative incidence of venous thromboembolism (VTE) in children with sickle cell disease (SCD) followed at a single institution and report on the risk factors associated with VTE development. Study design: Charts for all patients with SCD, aged 0-21 years, followed at Nationwide Children's Hospital over a 6-year period (January 1, 2009, to January 31, 2015) were reviewed. Data on VTE diagnosis, sex, body mass index/weight-for-length, SCD genotype, SCD clinical complications, central venous catheter (CVC) placement, and thrombophilia testing were collected. Results: Cumulative incidence of VTE in children with SCD followed at a single tertiary care institution was found to be 2.9% (12/414). Nine of the 12 VTE were CVC-associated. On univariate analysis, hemoglobin SS genotype (OR 10.7, 95% CI 1.4-83.5), CVC presence (OR 34.4, 95% CI 8.9-134.6), central nervous system vasculopathy (OR 19.4, 95% CI 5.6-63.4), chronic transfusion therapy (OR 30.6, 95% CI 8.9-122.2), and older age (P =.03) were associated with VTE. However, presence of CVC was the only independent risk factor identified on multivariable logistic regression analysis (OR 33.8, 95% CI 8.7-130.9). Conclusion: In our institution, nearly 3% of children with SCD had a history of VTE. CVC is an independent predictor of VTE in children with SCD.

Original languageEnglish (US)
Pages (from-to)186-190.e1
JournalJournal of Pediatrics
StatePublished - Jun 2018
Externally publishedYes


  • sickle cell disease
  • venous thromboembolism

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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