Venous Thromboembolism Prophylaxis after Total Knee Arthroplasty

Hayden N. Box, Sean Shahrestani, Michael H. Huo

Research output: Contribution to journalArticle

Abstract

Venous thromboembolic disease (VTED) is a major cause of morbidity and mortality after total knee arthroplasty (TKA). Current VTED prophylaxis protocols consist of early mobilization, mechanical compression devices, and pharmacologic agents. Venous phasic flow-regulated below-knee devices are generally favored, but the optimal duration and method of mechanical prophylaxis is unknown. Risk stratification models have been developed to guide pharmacologic prophylaxis. For patients with standard VTED risk profile, aspirin has become increasingly popular. Recent studies have validated the efficacy, relatively low bleeding risks, and cost-effectiveness of aspirin in the patients with standard risk profile. Current evidence suggests that the newer oral anticoagulants, including the factor Xa and the direct thrombin inhibitors, are effective for the reduction of postoperative VTED but may be associated with increased bleeding and wound complication rates.

Original languageEnglish (US)
JournalJournal of Knee Surgery
DOIs
StateAccepted/In press - Mar 7 2018

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Knee Replacement Arthroplasties
Venous Thromboembolism
Aspirin
Hemorrhage
Equipment and Supplies
Early Ambulation
Factor Xa
Antithrombins
Anticoagulants
Cost-Benefit Analysis
Knee
Morbidity
Mortality
Wounds and Injuries

Keywords

  • total knee arthroplasty
  • total knee arthroplasty complications
  • venous thromboembolism prophylaxis

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Venous Thromboembolism Prophylaxis after Total Knee Arthroplasty. / Box, Hayden N.; Shahrestani, Sean; Huo, Michael H.

In: Journal of Knee Surgery, 07.03.2018.

Research output: Contribution to journalArticle

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