Ventilation/perfusion imaging of the lung using ultra-short echo time (UTE) MRI in an animal model of pulmonary embolism

Osamu Togao, Yoshiharu Ohno, Ivan Dimitrov, Connie C. Hsia, Masaya Takahashi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Purpose: To test the feasibility of ultra-short echo time (UTE) MRI for assessment of regional pulmonary ventilation/perfusion in a standard 3 Tesla clinical MRI system. Materials and Methods: MRI of the lungs was conducted with an optimized three-dimensional UTE sequence in normal rats and in a rat model of pulmonary embolism (PE) induced by a blood clot. Changes in signal intensities (SIs) due to inhalation of molecular oxygen or intravenous (i.v.) injection of Gd, which represents the distribution of ventilation and perfusion, respectively, were assessed in the lung parenchyma. Results: The UTE MRI with a TE of 100 μs could detect and map the changes in SI of the lung parenchyma due to the inhalation of 100% oxygen or i.v. injection of Gd in normal rats. Reduced T1 resulting from oxygen inhalation was also quantified. These changes were not observed on the images that were obtained simultaneously with a conventional range of TE (2.3 ms). Furthermore, the method could delineate the embolized lesions where the lung ventilation and perfusion were mismatched in a rat model with PE. Conclusion: These results show the feasibility and diagnostic potential of UTE MRI for the assessment of pulmonary ventilation and perfusion which is essential for the evaluation of a variety of lung diseases.

Original languageEnglish (US)
Pages (from-to)539-546
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume34
Issue number3
DOIs
StatePublished - Sep 2011

Fingerprint

Perfusion Imaging
Pulmonary Embolism
Ventilation
Animal Models
Perfusion
Inhalation
Pulmonary Ventilation
Lung
Oxygen
Intravenous Injections
Lung Diseases
Thrombosis

Keywords

  • pulmonary embolism
  • pulmonary MRI
  • pulmonary perfusion
  • ultra-short echo time (UTE) MRI
  • ventilation
  • ventilation-perfusion mismatch

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Ventilation/perfusion imaging of the lung using ultra-short echo time (UTE) MRI in an animal model of pulmonary embolism. / Togao, Osamu; Ohno, Yoshiharu; Dimitrov, Ivan; Hsia, Connie C.; Takahashi, Masaya.

In: Journal of Magnetic Resonance Imaging, Vol. 34, No. 3, 09.2011, p. 539-546.

Research output: Contribution to journalArticle

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