Ventricular constraint using the acorn cardiac support device reduces myocardial akinetic area in an ovine model of acute infarction

James J. Pilla, Aaron S. Blom, Daniel J. Brockman, Frank Bowen, Qing Yuan, Joseph Giammarco, Victor A. Ferrari, Joseph H. Gorman, Robert C. Gorman, Michael A. Acker

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Background - Left ventricular remodeling secondary to acute myocardial infarction (AMI) is characterized by ventricular dilatation and regional akinesis. In this study, we investigated the effect of passive constraint on akinetic area development. Methods and Results - The effect of passive constraint on akinetic area was investigated in 10 sheep using tissue-tagging magnetic resonance imaging (MRI). A baseline MRI study was followed by the creation of an anterior infarct. After 1 week, the animals received a second MRI study. A cardiac support device (CSD) was then placed over the epicardium in 5 sheep whereas the remaining animals served as controls. A terminal study was performed at the 2-month postinfarct in both groups. The akinetic area at 1-week postinfarct was similar in both groups. At the terminal time-point, the akinetic area in the control group was similar to the 1-week time-point whereas in the CSD group, the area of akinesis decreased (P=0.001). A comparison of the 2 groups at the terminal time-point demonstrates a significantly diminished area of akinesis in the CSD group (P=0.004). The relative area of akinesis followed a similar pattern. End-systolic and end-diastolic wall thickness was significantly greater in the CSD group at terminal (P=0.001). In addition, the minimum wall thickness was greater in the CSD group compared with the controls (P=0.04). Conclusions - Passive constraint reduced akinetic area development secondary to AMI. The attenuation of regional wall stress may prevent the incorporation of the border zone into the infarct, decreasing infarct size and providing a promising new therapy for patients after an AMI.

Original languageEnglish (US)
JournalCirculation
Volume106
Issue number13 SUPPL.
StatePublished - Sep 24 2002

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Infarction
Sheep
Equipment and Supplies
Myocardial Infarction
Magnetic Resonance Imaging
Ventricular Remodeling
Pericardium
Dilatation
Control Groups
Therapeutics

Keywords

  • Magnetic resonance imaging
  • Myocardial infarction
  • Remodeling
  • Ventricles

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Pilla, J. J., Blom, A. S., Brockman, D. J., Bowen, F., Yuan, Q., Giammarco, J., ... Acker, M. A. (2002). Ventricular constraint using the acorn cardiac support device reduces myocardial akinetic area in an ovine model of acute infarction. Circulation, 106(13 SUPPL.).

Ventricular constraint using the acorn cardiac support device reduces myocardial akinetic area in an ovine model of acute infarction. / Pilla, James J.; Blom, Aaron S.; Brockman, Daniel J.; Bowen, Frank; Yuan, Qing; Giammarco, Joseph; Ferrari, Victor A.; Gorman, Joseph H.; Gorman, Robert C.; Acker, Michael A.

In: Circulation, Vol. 106, No. 13 SUPPL., 24.09.2002.

Research output: Contribution to journalArticle

Pilla, JJ, Blom, AS, Brockman, DJ, Bowen, F, Yuan, Q, Giammarco, J, Ferrari, VA, Gorman, JH, Gorman, RC & Acker, MA 2002, 'Ventricular constraint using the acorn cardiac support device reduces myocardial akinetic area in an ovine model of acute infarction', Circulation, vol. 106, no. 13 SUPPL..
Pilla, James J. ; Blom, Aaron S. ; Brockman, Daniel J. ; Bowen, Frank ; Yuan, Qing ; Giammarco, Joseph ; Ferrari, Victor A. ; Gorman, Joseph H. ; Gorman, Robert C. ; Acker, Michael A. / Ventricular constraint using the acorn cardiac support device reduces myocardial akinetic area in an ovine model of acute infarction. In: Circulation. 2002 ; Vol. 106, No. 13 SUPPL.
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abstract = "Background - Left ventricular remodeling secondary to acute myocardial infarction (AMI) is characterized by ventricular dilatation and regional akinesis. In this study, we investigated the effect of passive constraint on akinetic area development. Methods and Results - The effect of passive constraint on akinetic area was investigated in 10 sheep using tissue-tagging magnetic resonance imaging (MRI). A baseline MRI study was followed by the creation of an anterior infarct. After 1 week, the animals received a second MRI study. A cardiac support device (CSD) was then placed over the epicardium in 5 sheep whereas the remaining animals served as controls. A terminal study was performed at the 2-month postinfarct in both groups. The akinetic area at 1-week postinfarct was similar in both groups. At the terminal time-point, the akinetic area in the control group was similar to the 1-week time-point whereas in the CSD group, the area of akinesis decreased (P=0.001). A comparison of the 2 groups at the terminal time-point demonstrates a significantly diminished area of akinesis in the CSD group (P=0.004). The relative area of akinesis followed a similar pattern. End-systolic and end-diastolic wall thickness was significantly greater in the CSD group at terminal (P=0.001). In addition, the minimum wall thickness was greater in the CSD group compared with the controls (P=0.04). Conclusions - Passive constraint reduced akinetic area development secondary to AMI. The attenuation of regional wall stress may prevent the incorporation of the border zone into the infarct, decreasing infarct size and providing a promising new therapy for patients after an AMI.",
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AU - Pilla, James J.

AU - Blom, Aaron S.

AU - Brockman, Daniel J.

AU - Bowen, Frank

AU - Yuan, Qing

AU - Giammarco, Joseph

AU - Ferrari, Victor A.

AU - Gorman, Joseph H.

AU - Gorman, Robert C.

AU - Acker, Michael A.

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N2 - Background - Left ventricular remodeling secondary to acute myocardial infarction (AMI) is characterized by ventricular dilatation and regional akinesis. In this study, we investigated the effect of passive constraint on akinetic area development. Methods and Results - The effect of passive constraint on akinetic area was investigated in 10 sheep using tissue-tagging magnetic resonance imaging (MRI). A baseline MRI study was followed by the creation of an anterior infarct. After 1 week, the animals received a second MRI study. A cardiac support device (CSD) was then placed over the epicardium in 5 sheep whereas the remaining animals served as controls. A terminal study was performed at the 2-month postinfarct in both groups. The akinetic area at 1-week postinfarct was similar in both groups. At the terminal time-point, the akinetic area in the control group was similar to the 1-week time-point whereas in the CSD group, the area of akinesis decreased (P=0.001). A comparison of the 2 groups at the terminal time-point demonstrates a significantly diminished area of akinesis in the CSD group (P=0.004). The relative area of akinesis followed a similar pattern. End-systolic and end-diastolic wall thickness was significantly greater in the CSD group at terminal (P=0.001). In addition, the minimum wall thickness was greater in the CSD group compared with the controls (P=0.04). Conclusions - Passive constraint reduced akinetic area development secondary to AMI. The attenuation of regional wall stress may prevent the incorporation of the border zone into the infarct, decreasing infarct size and providing a promising new therapy for patients after an AMI.

AB - Background - Left ventricular remodeling secondary to acute myocardial infarction (AMI) is characterized by ventricular dilatation and regional akinesis. In this study, we investigated the effect of passive constraint on akinetic area development. Methods and Results - The effect of passive constraint on akinetic area was investigated in 10 sheep using tissue-tagging magnetic resonance imaging (MRI). A baseline MRI study was followed by the creation of an anterior infarct. After 1 week, the animals received a second MRI study. A cardiac support device (CSD) was then placed over the epicardium in 5 sheep whereas the remaining animals served as controls. A terminal study was performed at the 2-month postinfarct in both groups. The akinetic area at 1-week postinfarct was similar in both groups. At the terminal time-point, the akinetic area in the control group was similar to the 1-week time-point whereas in the CSD group, the area of akinesis decreased (P=0.001). A comparison of the 2 groups at the terminal time-point demonstrates a significantly diminished area of akinesis in the CSD group (P=0.004). The relative area of akinesis followed a similar pattern. End-systolic and end-diastolic wall thickness was significantly greater in the CSD group at terminal (P=0.001). In addition, the minimum wall thickness was greater in the CSD group compared with the controls (P=0.04). Conclusions - Passive constraint reduced akinetic area development secondary to AMI. The attenuation of regional wall stress may prevent the incorporation of the border zone into the infarct, decreasing infarct size and providing a promising new therapy for patients after an AMI.

KW - Magnetic resonance imaging

KW - Myocardial infarction

KW - Remodeling

KW - Ventricles

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