Verification of enhancement of the CSF space, not parenchyma, in acute stroke patients with early blood-brain barrier disruption

Erica C. Henning, Lawrence L. Latour, Steven Warach

Research output: Contribution to journalArticle

26 Scopus citations


Enhancement on post-contrast fluid-attenuated inversion recovery (FLAIR) images after acute stroke has been attributed to early blood-brain barrier disruption. Using an estimate of parenchymal volume fraction and the apparent diffusion coefficient (ADC), we investigated the relative contributions of cerebral spinal fluid (CSF) and parenchyma to enhancement seen on postcontrast FLAIR. Enhancing regions were found to have low parenchymal volume fractions and high ADC values, approaching that of pure CSF. These findings suggest that contrast enhancement on FLAIR occurs predominately in the CSF space, not parenchyma.

Original languageEnglish (US)
Pages (from-to)882-886
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number5
StatePublished - May 1 2008



  • ADC
  • Blood-brain barrier
  • CSF
  • HARM
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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