Abstract
Purpose Measurement of venous oxygenation (Yv) is a critical step toward quantitative assessment of brain oxygen metabolism, a key index in many brain disorders. The present study aims to develop a noninvasive, rapid, and reproducible method to measure Yv in a vessel-specific manner. Theory The method, T2-Relaxation-Under-Phase-Contrast MRI, utilizes complex subtraction of phase-contrast to isolate pure blood signal, applies nonslice-selective T2-preparation to measure T2, and converts T2 to oxygenation using a calibration plot. Methods Following feasibility demonstration, several technical aspects were examined, including validation with an established global Yv technique, test-retest reproducibility, sensitivity to detect oxygenation changes due to hypoxia and caffeine challenges, applicability of echo-planar-imaging (EPI) acquisition to shorten scan duration, and ability to study veins with a caliber of 1-2 mm. Results T2-Relaxation-Under-Phase-Contrast was able to simultaneously measure Yv in all major veins in the brain, including sagittal sinus, straight sinus, great vein, and internal cerebral vein. T 2-Relaxation-Under-Phase-Contrast results showed an excellent agreement with the reference technique, high sensitivity to oxygenation changes, and test-retest variability of 3.5 ± 1.0%. The use of segmented-EPI was able to reduce the scan duration to 1.5 minutes. It was also feasible to study pial veins and deep veins. Conclusion T2-Relaxation-Under-Phase- Contrast MRI is a promising technique for vessel-specific oxygenation measurement.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 978-989 |
| Number of pages | 12 |
| Journal | Magnetic Resonance in Medicine |
| Volume | 71 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2014 |
Fingerprint
Keywords
- blood oxygen saturation
- CMRO
- small vessel
- TRU-PC
- TRUST
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Vessel-specific quantification of blood oxygenation with T 2-relaxation-under-phase-contrast MRI. / Krishnamurthy, Lisa C.; Liu, Peiying; Ge, Yulin; Lu, Hanzhang.
In: Magnetic Resonance in Medicine, Vol. 71, No. 3, 03.2014, p. 978-989.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vessel-specific quantification of blood oxygenation with T 2-relaxation-under-phase-contrast MRI
AU - Krishnamurthy, Lisa C.
AU - Liu, Peiying
AU - Ge, Yulin
AU - Lu, Hanzhang
PY - 2014/3
Y1 - 2014/3
N2 - Purpose Measurement of venous oxygenation (Yv) is a critical step toward quantitative assessment of brain oxygen metabolism, a key index in many brain disorders. The present study aims to develop a noninvasive, rapid, and reproducible method to measure Yv in a vessel-specific manner. Theory The method, T2-Relaxation-Under-Phase-Contrast MRI, utilizes complex subtraction of phase-contrast to isolate pure blood signal, applies nonslice-selective T2-preparation to measure T2, and converts T2 to oxygenation using a calibration plot. Methods Following feasibility demonstration, several technical aspects were examined, including validation with an established global Yv technique, test-retest reproducibility, sensitivity to detect oxygenation changes due to hypoxia and caffeine challenges, applicability of echo-planar-imaging (EPI) acquisition to shorten scan duration, and ability to study veins with a caliber of 1-2 mm. Results T2-Relaxation-Under-Phase-Contrast was able to simultaneously measure Yv in all major veins in the brain, including sagittal sinus, straight sinus, great vein, and internal cerebral vein. T 2-Relaxation-Under-Phase-Contrast results showed an excellent agreement with the reference technique, high sensitivity to oxygenation changes, and test-retest variability of 3.5 ± 1.0%. The use of segmented-EPI was able to reduce the scan duration to 1.5 minutes. It was also feasible to study pial veins and deep veins. Conclusion T2-Relaxation-Under-Phase- Contrast MRI is a promising technique for vessel-specific oxygenation measurement.
AB - Purpose Measurement of venous oxygenation (Yv) is a critical step toward quantitative assessment of brain oxygen metabolism, a key index in many brain disorders. The present study aims to develop a noninvasive, rapid, and reproducible method to measure Yv in a vessel-specific manner. Theory The method, T2-Relaxation-Under-Phase-Contrast MRI, utilizes complex subtraction of phase-contrast to isolate pure blood signal, applies nonslice-selective T2-preparation to measure T2, and converts T2 to oxygenation using a calibration plot. Methods Following feasibility demonstration, several technical aspects were examined, including validation with an established global Yv technique, test-retest reproducibility, sensitivity to detect oxygenation changes due to hypoxia and caffeine challenges, applicability of echo-planar-imaging (EPI) acquisition to shorten scan duration, and ability to study veins with a caliber of 1-2 mm. Results T2-Relaxation-Under-Phase-Contrast was able to simultaneously measure Yv in all major veins in the brain, including sagittal sinus, straight sinus, great vein, and internal cerebral vein. T 2-Relaxation-Under-Phase-Contrast results showed an excellent agreement with the reference technique, high sensitivity to oxygenation changes, and test-retest variability of 3.5 ± 1.0%. The use of segmented-EPI was able to reduce the scan duration to 1.5 minutes. It was also feasible to study pial veins and deep veins. Conclusion T2-Relaxation-Under-Phase- Contrast MRI is a promising technique for vessel-specific oxygenation measurement.
KW - blood oxygen saturation
KW - CMRO
KW - small vessel
KW - TRU-PC
KW - TRUST
UR - http://www.scopus.com/inward/record.url?scp=84894434471&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84894434471&partnerID=8YFLogxK
U2 - 10.1002/mrm.24750
DO - 10.1002/mrm.24750
M3 - Article
C2 - 23568830
AN - SCOPUS:84894434471
VL - 71
SP - 978
EP - 989
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
IS - 3
ER -