Viral immunity

Transkingdom control of viral infection and immunity in the mammalian intestine

Julie K. Pfeiffer, Herbert W. Virgin

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Viruses that infect the intestine include major human pathogens (retroviruses, noroviruses, rotaviruses, astroviruses, picornaviruses, adenoviruses, herpesviruses) that constitute a serious public health problem worldwide. These viral pathogens are members of a large, complex viral community inhabiting the intestine termed "the enteric virome." Enteric viruses have intimate functional and genetic relationships with both the host and othermicrobial constituents that inhabit the intestine, such as the bacterial microbiota, their associated phages, helminthes, and fungi, which together constitute the microbiome. Emerging data indicate that enteric viruses regulate, and are in turn regulated by, these other microbes through a series of processes termed "transkingdom interactions." This represents a changing paradigm in intestinal immunity to viral infection. Here we review recent advances in the field and propose new ways in which to conceptualize this important area.

Original languageEnglish (US)
Article numberaad5872
JournalScience
Volume351
Issue number6270
DOIs
StatePublished - Jan 15 2016

Fingerprint

Virus Diseases
Intestines
Immunity
Enterovirus
Microbiota
Picornaviridae
Norovirus
Rotavirus
Herpesviridae
Retroviridae
Adenoviridae
Bacteriophages
Fungi
Public Health
Viruses

ASJC Scopus subject areas

  • General

Cite this

Viral immunity : Transkingdom control of viral infection and immunity in the mammalian intestine. / Pfeiffer, Julie K.; Virgin, Herbert W.

In: Science, Vol. 351, No. 6270, aad5872, 15.01.2016.

Research output: Contribution to journalArticle

@article{de3bf51ff3914b0997be5b2a2624415b,
title = "Viral immunity: Transkingdom control of viral infection and immunity in the mammalian intestine",
abstract = "Viruses that infect the intestine include major human pathogens (retroviruses, noroviruses, rotaviruses, astroviruses, picornaviruses, adenoviruses, herpesviruses) that constitute a serious public health problem worldwide. These viral pathogens are members of a large, complex viral community inhabiting the intestine termed {"}the enteric virome.{"} Enteric viruses have intimate functional and genetic relationships with both the host and othermicrobial constituents that inhabit the intestine, such as the bacterial microbiota, their associated phages, helminthes, and fungi, which together constitute the microbiome. Emerging data indicate that enteric viruses regulate, and are in turn regulated by, these other microbes through a series of processes termed {"}transkingdom interactions.{"} This represents a changing paradigm in intestinal immunity to viral infection. Here we review recent advances in the field and propose new ways in which to conceptualize this important area.",
author = "Pfeiffer, {Julie K.} and Virgin, {Herbert W.}",
year = "2016",
month = "1",
day = "15",
doi = "10.1126/science.aad5872",
language = "English (US)",
volume = "351",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6270",

}

TY - JOUR

T1 - Viral immunity

T2 - Transkingdom control of viral infection and immunity in the mammalian intestine

AU - Pfeiffer, Julie K.

AU - Virgin, Herbert W.

PY - 2016/1/15

Y1 - 2016/1/15

N2 - Viruses that infect the intestine include major human pathogens (retroviruses, noroviruses, rotaviruses, astroviruses, picornaviruses, adenoviruses, herpesviruses) that constitute a serious public health problem worldwide. These viral pathogens are members of a large, complex viral community inhabiting the intestine termed "the enteric virome." Enteric viruses have intimate functional and genetic relationships with both the host and othermicrobial constituents that inhabit the intestine, such as the bacterial microbiota, their associated phages, helminthes, and fungi, which together constitute the microbiome. Emerging data indicate that enteric viruses regulate, and are in turn regulated by, these other microbes through a series of processes termed "transkingdom interactions." This represents a changing paradigm in intestinal immunity to viral infection. Here we review recent advances in the field and propose new ways in which to conceptualize this important area.

AB - Viruses that infect the intestine include major human pathogens (retroviruses, noroviruses, rotaviruses, astroviruses, picornaviruses, adenoviruses, herpesviruses) that constitute a serious public health problem worldwide. These viral pathogens are members of a large, complex viral community inhabiting the intestine termed "the enteric virome." Enteric viruses have intimate functional and genetic relationships with both the host and othermicrobial constituents that inhabit the intestine, such as the bacterial microbiota, their associated phages, helminthes, and fungi, which together constitute the microbiome. Emerging data indicate that enteric viruses regulate, and are in turn regulated by, these other microbes through a series of processes termed "transkingdom interactions." This represents a changing paradigm in intestinal immunity to viral infection. Here we review recent advances in the field and propose new ways in which to conceptualize this important area.

UR - http://www.scopus.com/inward/record.url?scp=84954442290&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84954442290&partnerID=8YFLogxK

U2 - 10.1126/science.aad5872

DO - 10.1126/science.aad5872

M3 - Article

VL - 351

JO - Science

JF - Science

SN - 0036-8075

IS - 6270

M1 - aad5872

ER -