Viral immunity: Transkingdom control of viral infection and immunity in the mammalian intestine

Julie K. Pfeiffer, Herbert W. Virgin

Research output: Contribution to journalArticle

110 Scopus citations

Abstract

Viruses that infect the intestine include major human pathogens (retroviruses, noroviruses, rotaviruses, astroviruses, picornaviruses, adenoviruses, herpesviruses) that constitute a serious public health problem worldwide. These viral pathogens are members of a large, complex viral community inhabiting the intestine termed "the enteric virome." Enteric viruses have intimate functional and genetic relationships with both the host and othermicrobial constituents that inhabit the intestine, such as the bacterial microbiota, their associated phages, helminthes, and fungi, which together constitute the microbiome. Emerging data indicate that enteric viruses regulate, and are in turn regulated by, these other microbes through a series of processes termed "transkingdom interactions." This represents a changing paradigm in intestinal immunity to viral infection. Here we review recent advances in the field and propose new ways in which to conceptualize this important area.

Original languageEnglish (US)
Article numberaad5872
JournalScience
Volume351
Issue number6270
DOIs
StatePublished - Jan 15 2016

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Viral immunity: Transkingdom control of viral infection and immunity in the mammalian intestine'. Together they form a unique fingerprint.

  • Cite this