Viral interactions with the nuclear transport machinery

Discovering and disrupting pathways

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Viruses have been invaluable tools for discovering key pathways of nucleocytoplasmic transport. Conversely, disruption of specific nuclear transport pathways, are crucial for the productive life cycle of some viruses. The major cellular mRNA export pathway, which uses TAP (NXF1)/p15(NXT) as receptor, was discovered as a result of TAP interaction with CTE-containing RNAs from Mason-Pfizer Monkey Virus. In addition, CRM1 or exportin 1, which is a transport receptor that mediates nuclear export of proteins, snRNAs, rRNAs and a small subset of mRNAs, was discovered as an interacting partner of the Rev protein of HIV1. Viruses may disrupt the nuclear transport machinery to prevent host antiviral response. VSV Matrix (M) protein inhibits mRNA export by forming a complex with the mRNA export factor Rae1 whereas poliovirus inhibits nuclear import of proteins by probably degrading Nup62 and Nup153. Hence, this review focuses on viruses as tools and as disruptors of nucleocytoplasmic trafficking.

Original languageEnglish (US)
Pages (from-to)65-72
Number of pages8
JournalIUBMB Life
Volume57
Issue number2
DOIs
StatePublished - Feb 2005

Fingerprint

Cell Nucleus Active Transport
Viruses
Machinery
Messenger RNA
Nuclear Proteins
Mason-Pfizer monkey virus
rev Gene Products
Proteins
Poliovirus
Cytoplasmic and Nuclear Receptors
Life Cycle Stages
Antiviral Agents
Life cycle
RNA

Keywords

  • Exportin
  • Importin
  • Interferon
  • Karyopherin
  • Nuclear pore complex
  • Nuclear transport
  • TAP
  • VSV

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Viral interactions with the nuclear transport machinery : Discovering and disrupting pathways. / Fontoura, Beatriz M A; Faria, Paula A.; Nussenzveig, Daniel R.

In: IUBMB Life, Vol. 57, No. 2, 02.2005, p. 65-72.

Research output: Contribution to journalArticle

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