TY - JOUR
T1 - Viral–host interactions during splicing and nuclear export of influenza virus mRNAs
AU - Esparza, Matthew
AU - Bhat, Prasanna
AU - Fontoura, Beatriz MA
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/8
Y1 - 2022/8
N2 - As influenza-A viruses (IAV) replicate in the host cell nucleus, intranuclear pathways are usurped for viral gene expression. The eight genomic viral ribonucleoproteins (vRNPs) segments of IAV are transcribed and two generate viral mRNAs (M and NS) that undergo alternative splicing followed by export from the nucleus. The focus of this review is on viral RNA splicing and nuclear export. Recent mechanistic advances on M and NS splicing show differential regulation by RNA-binding proteins as well as distinct intranuclear localization. After a review of IAV splicing, we will discuss the nuclear export of viral mRNAs, which occur by interacting with specific constituents of the host mRNA export machinery that translocate viral mRNAs through the nuclear pore complex for translation in the cytoplasm.
AB - As influenza-A viruses (IAV) replicate in the host cell nucleus, intranuclear pathways are usurped for viral gene expression. The eight genomic viral ribonucleoproteins (vRNPs) segments of IAV are transcribed and two generate viral mRNAs (M and NS) that undergo alternative splicing followed by export from the nucleus. The focus of this review is on viral RNA splicing and nuclear export. Recent mechanistic advances on M and NS splicing show differential regulation by RNA-binding proteins as well as distinct intranuclear localization. After a review of IAV splicing, we will discuss the nuclear export of viral mRNAs, which occur by interacting with specific constituents of the host mRNA export machinery that translocate viral mRNAs through the nuclear pore complex for translation in the cytoplasm.
UR - http://www.scopus.com/inward/record.url?scp=85135107758&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85135107758&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2022.101254
DO - 10.1016/j.coviro.2022.101254
M3 - Review article
C2 - 35908311
AN - SCOPUS:85135107758
SN - 1879-6257
VL - 55
JO - Current Opinion in Virology
JF - Current Opinion in Virology
M1 - 101254
ER -