Virilization persists in a woman with an androgen-secreting granulosa cell tumor

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11 Scopus citations

Abstract

Objective: To report a case of a woman who presented with amenorrhea and masculinization secondary to an androgen-secreting granulosa cell (GC) tumor, with refractory masculinization. Design: Case report. Setting: University medical center. Patient(s): A 45-year-old woman with abrupt onset of virilization with high serum androgen levels. Intervention(s): Exploratory laparotomy with full staging. Main Outcome Measure(s): Surgical findings and histopathologic observations are included in this report. Result(s): Pathologic examination revealed an inhibin stain positive GC tumor of the adult type. Virilization has persisted for 8 years after surgery. Conclusion(s): Adult-type GC tumor is an extremely rare cause of virilization. Masculinization features may persist in the absence of high androgen levels.

Original languageEnglish (US)
Pages (from-to)933.e13-933.e15
JournalFertility and Sterility
Volume91
Issue number3
DOIs
StatePublished - Mar 2009

Keywords

  • Granulosa cell tumor
  • androgen
  • inhibin
  • testosterone
  • virilizing, masculinizing

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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