Virtual colonoscopy screening with ultra low-dose CT and less-stressful bowel preparation: A computer simulation study

Jing Wang, Su Wang, Lihong Li, Yi Fan, Hongbing Lu, Zhengrong Liang

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Computed tomography colonography (CTC) or CT-based virtual colonoscopy (VC) is an emerging tool for detection of colonic polyps. Compared to the conventional fiber-optic colonoscopy, VC has demonstrated the potential to become a mass screening modality in terms of safety, cost, and patient compliance. However, current CTC delivers excessive X-ray radiation to the patient during data acquisition. The radiation is a major concern for screening application of CTC. In this work, we performed a simulation study to demonstrate a possible ultra low-dose CT technique for VC. The ultra low-dose abdominal CT images were simulated by adding noise to the sinograms of the patient CTC images acquired with normal dose scans at 100 mAs levels. The simulated noisy sinogram or projection data were first processed by a Karhunen-Love domain penalized weighted least-squares (KL-PWLS) restoration method and then reconstructed by a filtered backprojection algorithm for the ultra low-dose CT images. The patient-specific virtual colon lumen was constructed and navigated by a VC system after electronic colon cleansing of the orally-tagged residue stool and fluid. By the KL-PWLS noise reduction, the colon lumen can successfully be constructed and the colonic polyp can be detected in an ultra low-dose level below 50 mAs. Polyp detection can be found more easily by the KL-PWLS noise reduction compared to the results using the conventional noise filters, such as Hanning filter. These promising results indicate the feasibility of an ultra low-dose CTC pipeline for colon screening with less-stressful bowel preparation by fecal tagging with oral contrast.

Original languageEnglish (US)
Article number4689420
Pages (from-to)2566-2575
Number of pages10
JournalIEEE Transactions on Nuclear Science
Volume55
Issue number5
DOIs
StatePublished - Oct 2008

Fingerprint

Tomography
Screening
screening
computerized simulation
tomography
dosage
preparation
Computer simulation
Noise abatement
lumens
noise reduction
Radiation
filters
Fiber optics
Restoration
radiation
Data acquisition
restoration
Pipelines
marking

Keywords

  • Karhunen-Love transform
  • Low dose computed tomography
  • Noise reduction
  • Partial volume image segmentation
  • Penalized weighted least-squares
  • Virtual colonoscopy

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Nuclear Energy and Engineering
  • Nuclear and High Energy Physics

Cite this

Virtual colonoscopy screening with ultra low-dose CT and less-stressful bowel preparation : A computer simulation study. / Wang, Jing; Wang, Su; Li, Lihong; Fan, Yi; Lu, Hongbing; Liang, Zhengrong.

In: IEEE Transactions on Nuclear Science, Vol. 55, No. 5, 4689420, 10.2008, p. 2566-2575.

Research output: Contribution to journalArticle

Wang, Jing ; Wang, Su ; Li, Lihong ; Fan, Yi ; Lu, Hongbing ; Liang, Zhengrong. / Virtual colonoscopy screening with ultra low-dose CT and less-stressful bowel preparation : A computer simulation study. In: IEEE Transactions on Nuclear Science. 2008 ; Vol. 55, No. 5. pp. 2566-2575.
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