TY - JOUR
T1 - Virulence determinants for Vibrio parahaemolyticus infection
AU - Zhang, Lingling
AU - Orth, Kim
N1 - Funding Information:
Thanks to the Orth Lab for the editing and insightful comments. K.O. and L.Z. are supported by National Institutes of Health-AID Grant R01-AI056404 and Grant I-1561 from the Welch Research Foundation. K.O. is a Burroughs Welcome Investigator in Pathogenesis of Infectious Disease and a W.W. Caruth, Jr. Biomedical Scholar.
PY - 2013/2
Y1 - 2013/2
N2 - Vibrio parahaemolyticus is a marine microorganism that causes acute gastroenteritis associated with the consumption of contaminated raw or under cooked seafood. During infection, the bacterium utilizes a wide variety of virulence factors, including adhesins, toxins and type III secretion systems, to cause both cytotoxicity in cultured cells and enterotoxicity in animal models. Herein, we describe recent discoveries on the regulation and characterization of the virulence factors from V. para. Determining how this bacterial pathogen uses virulence factors to mediate pathogenicity improves our understanding of V. para. infections and more generally, host-pathogen interactions.
AB - Vibrio parahaemolyticus is a marine microorganism that causes acute gastroenteritis associated with the consumption of contaminated raw or under cooked seafood. During infection, the bacterium utilizes a wide variety of virulence factors, including adhesins, toxins and type III secretion systems, to cause both cytotoxicity in cultured cells and enterotoxicity in animal models. Herein, we describe recent discoveries on the regulation and characterization of the virulence factors from V. para. Determining how this bacterial pathogen uses virulence factors to mediate pathogenicity improves our understanding of V. para. infections and more generally, host-pathogen interactions.
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U2 - 10.1016/j.mib.2013.02.002
DO - 10.1016/j.mib.2013.02.002
M3 - Review article
C2 - 23433802
AN - SCOPUS:84875812865
SN - 1369-5274
VL - 16
SP - 70
EP - 77
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 1
ER -