Virulent Treponema pallidum promotes adhesion of leukocytes to human vascular endothelial cells

B. S. Riley, N. Oppenheimer-Marks, J. D. Radolf, M. V. Norgard

Research output: Contribution to journalComment/debate

17 Scopus citations


Perivasculitis and endothelial cell abnormalities are characteristic histopathologic features of syphilis, a sexually transmitted disease caused by Treponema pallidum. To extend earlier studies demonstrating that T. pallidum activates endothelial cells, we now show that virulent T. pallidum, but not heat-killed T. pallidum or nonpathogenic Treponema phagedenis, promotes increased adherence of lymphocytes and monocytes to human umbilical vein endothelial cells. Lymphocytes and monocytes are the two cell types prominent in the histopathology of syphilis. Recognition that T. pallidum can stimulate endothelial cells to bind leukocytes provides important insights into the early mechanisms of syphilis immunopathogenesis.

Original languageEnglish (US)
Pages (from-to)4622-4625
Number of pages4
JournalInfection and immunity
Issue number10
StatePublished - Jan 1 1994


ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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