Virus-induced alterations in homeostasis: Alterations in differentiated functions of infected cells in vivo

Michael B.A. Oldstone, Y. N. Sinha, Paul Blount, Antoinette Tishon, Moses Rodriguez, Randall Von Wedel, Peter W. Lampert

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

The noncytopathic lymphocytic choriomeningitis virus displays a tropism for the anterior lobe of the murine pituitary gland. Virus replicates in cells that make growth hormone. This results in a diminished synthesis of growth hormone with a concomitant clinical picture of retarded growth and hypoglycemia. However, there is no morphologic evidence of either cell necrosis or inflammation in the anterior lobe of the pituitary. Hence, during infection in vivo, a noncytopathic virus may turn off the "differentiation" or "luxury" function of a cell while not killing that cell (loss of vital function). This in turn can disrupt homeostasis and cause disease. This model illustrates a novel way whereby viruses may cause disease.

Original languageEnglish (US)
Pages (from-to)1125-1127
Number of pages3
JournalScience
Volume218
Issue number4577
DOIs
StatePublished - Jan 1 1982

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Homeostasis
Viruses
Anterior Pituitary Gland
Growth Hormone
Lymphocytic choriomeningitis virus
Tropism
Pituitary Gland
Hypoglycemia
Necrosis
Inflammation
Growth
Infection

ASJC Scopus subject areas

  • General

Cite this

Oldstone, M. B. A., Sinha, Y. N., Blount, P., Tishon, A., Rodriguez, M., Von Wedel, R., & Lampert, P. W. (1982). Virus-induced alterations in homeostasis: Alterations in differentiated functions of infected cells in vivo. Science, 218(4577), 1125-1127. https://doi.org/10.1126/science.7146898

Virus-induced alterations in homeostasis : Alterations in differentiated functions of infected cells in vivo. / Oldstone, Michael B.A.; Sinha, Y. N.; Blount, Paul; Tishon, Antoinette; Rodriguez, Moses; Von Wedel, Randall; Lampert, Peter W.

In: Science, Vol. 218, No. 4577, 01.01.1982, p. 1125-1127.

Research output: Contribution to journalArticle

Oldstone, MBA, Sinha, YN, Blount, P, Tishon, A, Rodriguez, M, Von Wedel, R & Lampert, PW 1982, 'Virus-induced alterations in homeostasis: Alterations in differentiated functions of infected cells in vivo', Science, vol. 218, no. 4577, pp. 1125-1127. https://doi.org/10.1126/science.7146898
Oldstone, Michael B.A. ; Sinha, Y. N. ; Blount, Paul ; Tishon, Antoinette ; Rodriguez, Moses ; Von Wedel, Randall ; Lampert, Peter W. / Virus-induced alterations in homeostasis : Alterations in differentiated functions of infected cells in vivo. In: Science. 1982 ; Vol. 218, No. 4577. pp. 1125-1127.
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