Visceral fat adipokine secretion is associated with systemic inflammation in obese humans

Luigi Fontana, J. Christopher Eagon, Maria E. Trujillo, Philipp E. Scherer, Samuel Klein

Research output: Contribution to journalArticle

668 Citations (Scopus)

Abstract

Although excess visceral fat is associated with noninfectious inflammation, it is not clear whether visceral fat is simply associated with or actually causes metabolic disease in humans. To evaluate the hypothesis that visceral fat promotes systemic inflammation by secreting inflammatory adipokines into the portal circulation that drains visceral fat, we determined adipokine arteriovenous concentration differences across visceral fat, by obtaining portal vein and radial artery blood samples, in 25 extremely obese subjects (mean ± SD BMI 54.7 ± 12.6 kg/m2) during gastric bypass surgery at Barnes-Jewish Hospital in St. Louis, Missouri. Mean plasma interleukin (IL)-6 concentration was ∼50% greater in the portal vein than in the radial artery in obese subjects (P = 0.007). Portal vein IL-6 concentration correlated directly with systemic C-reactive protein concentrations (r = 0.544, P = 0.005). Mean plasma leptin concentration was ∼20% lower in the portal vein than in the radial artery in obese subjects (P = 0.0002). Plasma tumor necrosis factor-α, resistin, macrophage chemoattractant protein-1, and adiponectin concentrations were similar in the portal vein and radial artery in obese subjects. These data suggest that visceral fat is an important site for IL-6 secretion and provide a potential mechanistic link between visceral fat and systemic inflammation in people with abdominal obesity.

Original languageEnglish (US)
Pages (from-to)1010-1013
Number of pages4
JournalDiabetes
Volume56
Issue number4
DOIs
StatePublished - Apr 2007

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Adipokines
Intra-Abdominal Fat
Portal Vein
Radial Artery
Inflammation
Interleukin-6
Resistin
Gastric Bypass
Abdominal Obesity
Adiponectin
Chemotactic Factors
Metabolic Diseases
Leptin
C-Reactive Protein
Tumor Necrosis Factor-alpha
Macrophages

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. / Fontana, Luigi; Eagon, J. Christopher; Trujillo, Maria E.; Scherer, Philipp E.; Klein, Samuel.

In: Diabetes, Vol. 56, No. 4, 04.2007, p. 1010-1013.

Research output: Contribution to journalArticle

Fontana, Luigi ; Eagon, J. Christopher ; Trujillo, Maria E. ; Scherer, Philipp E. ; Klein, Samuel. / Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. In: Diabetes. 2007 ; Vol. 56, No. 4. pp. 1010-1013.
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