Visible Light Induced Brønsted Acid Assisted Pd-Catalyzed Alkyl Heck Reaction of Diazo Compounds and N-Tosylhydrazones

Ziyan Zhang, Nikita Kvasovs, Anastasiia Dubrovina, Vladimir Gevorgyan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A mild visible light-induced palladium-catalyzed alkyl Heck reaction of diazo compounds and N-tosylhydrazones is reported. A broad range of vinyl arenes and heteroarenes with high functional group tolerance, as well as a range of different diazo compounds, can efficiently undergo this transformation. This method features Brønsted acid-assisted generation of hybrid palladium C(sp3)-centered radical intermediate, which allowed for new selective C−H functionalization protocol.

Original languageEnglish (US)
Article numbere202110924
JournalAngewandte Chemie - International Edition
Volume61
Issue number1
DOIs
StatePublished - Jan 3 2022
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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