Visual prognostic value of the pattern electroretinogram in chiasmal compression

D. N. Parmar, A. Sofat, Robert W Bowman, J. R. Barlett, G. E. Holder

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Backgroundlaims-The visual loss associated with compression of the optic chiasm by pituitary tumours may be transient or permanent, possibly related to the extent of irreversible retrograde degeneration to the retinal ganglion cells. The pattern electroretinogram (PERG) N95 component is thought to rise in relation to retinal ganglion cell function and hence may be a potential prognostic indicator for visual function following decompressive surgery. Methods-The notes and electrodiagnostic records of 72 eyes from 36 patients with chiasmal compression were retrospectively analysed. Results-The postoperative change in visual field was found to be associated with the PERG N95:P50 ratio (p=0.01). Improvement in visual field was shown by a greater proportion of eyes with a normal N95:P50 ratio (65%) than with an abnormal ratio (27%). No change in visual field occurred in 26% of the eyes with a normal N95:P50 ratio compared with 67% of those with an abnormal ratio. Only 8% of eyes showed a worsening of visual field following surgery, in similar proportions for eyes with normal and abnormal N95:P50 ratios. There was no significant relationship with visual acuity. Conclusion-The PERG is a useful visual prognostic indicator in the preoperative assessment of chiasmal compression.

Original languageEnglish (US)
Pages (from-to)1024-1026
Number of pages3
JournalBritish Journal of Ophthalmology
Volume84
Issue number9
DOIs
StatePublished - 2000

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Visual Fields
Retinal Ganglion Cells
Retrograde Degeneration
Optic Chiasm
Pituitary Neoplasms
Visual Acuity

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Visual prognostic value of the pattern electroretinogram in chiasmal compression. / Parmar, D. N.; Sofat, A.; Bowman, Robert W; Barlett, J. R.; Holder, G. E.

In: British Journal of Ophthalmology, Vol. 84, No. 9, 2000, p. 1024-1026.

Research output: Contribution to journalArticle

Parmar, D. N. ; Sofat, A. ; Bowman, Robert W ; Barlett, J. R. ; Holder, G. E. / Visual prognostic value of the pattern electroretinogram in chiasmal compression. In: British Journal of Ophthalmology. 2000 ; Vol. 84, No. 9. pp. 1024-1026.
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