Visualizing and quantifying adhesive signals

Mohsen Sabouri-Ghomi, Yi Wu, Klaus Hahn, Gaudenz Danuser

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

Understanding the structural adaptation and signaling of adhesion sites in response to mechanical stimuli requires in situ characterization of the dynamic activation of a large number of adhesion components. Here, we review high-resolution live cell imaging approaches to measure forces, assembly, and interaction of adhesion components, and the activation of adhesion-mediated signals. We conclude by outlining computational multiplexing as a framework for the integration of these data into comprehensive models of adhesion signaling pathways.

Original languageEnglish (US)
Pages (from-to)541-550
Number of pages10
JournalCurrent Opinion in Cell Biology
Volume20
Issue number5
DOIs
StatePublished - Oct 1 2008

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ASJC Scopus subject areas

  • Cell Biology

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