Visualizing and quantifying adhesive signals

Mohsen Sabouri-Ghomi, Yi Wu, Klaus Hahn, Gaudenz Danuser

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

Understanding the structural adaptation and signaling of adhesion sites in response to mechanical stimuli requires in situ characterization of the dynamic activation of a large number of adhesion components. Here, we review high-resolution live cell imaging approaches to measure forces, assembly, and interaction of adhesion components, and the activation of adhesion-mediated signals. We conclude by outlining computational multiplexing as a framework for the integration of these data into comprehensive models of adhesion signaling pathways.

Original languageEnglish (US)
Pages (from-to)541-550
Number of pages10
JournalCurrent Opinion in Cell Biology
Volume20
Issue number5
DOIs
StatePublished - Oct 1 2008

ASJC Scopus subject areas

  • Cell Biology

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