Visualizing and quantifying adhesive signals

Mohsen Sabouri-Ghomi, Yi Wu, Klaus Hahn, Gaudenz Danuser

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Understanding the structural adaptation and signaling of adhesion sites in response to mechanical stimuli requires in situ characterization of the dynamic activation of a large number of adhesion components. Here, we review high-resolution live cell imaging approaches to measure forces, assembly, and interaction of adhesion components, and the activation of adhesion-mediated signals. We conclude by outlining computational multiplexing as a framework for the integration of these data into comprehensive models of adhesion signaling pathways.

Original languageEnglish (US)
Pages (from-to)541-550
Number of pages10
JournalCurrent Opinion in Cell Biology
Volume20
Issue number5
DOIs
StatePublished - Oct 2008

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ASJC Scopus subject areas

  • Cell Biology

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Visualizing and quantifying adhesive signals. / Sabouri-Ghomi, Mohsen; Wu, Yi; Hahn, Klaus; Danuser, Gaudenz.

In: Current Opinion in Cell Biology, Vol. 20, No. 5, 10.2008, p. 541-550.

Research output: Contribution to journalArticle

Sabouri-Ghomi, Mohsen ; Wu, Yi ; Hahn, Klaus ; Danuser, Gaudenz. / Visualizing and quantifying adhesive signals. In: Current Opinion in Cell Biology. 2008 ; Vol. 20, No. 5. pp. 541-550.
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