Visualizing cancer and immune cell function with metabolic positron emission tomography

Rachel E. Laing; Evan Nair-Gill; Owen N. Witte; Caius G. Radu

doi:10.1016/j.gde.2009.10.008

Visualizing cancer and immune cell function with metabolic positron emission tomography

Rachel E. Laing, Evan Nair-Gill, Owen N. Witte, Caius G. Radu

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Cancer cells and immune cells modulate their metabolism according to specific needs during cancer progression and immune responses. The ability to measure cellular metabolic function in vivo would enable the evaluation of tumors and their response to therapy and also the effectiveness of cellular immune responses to cancer. Positron emission tomography (PET) is a highly sensitive clinical imaging modality that enables whole-body, quantitative measurements of tissue biochemical function. Here, we review work using PET probes for specific metabolic pathways to measure cell function in cancer and immunity. We focus on the use of probes for glycolysis and nucleoside salvage and then discuss the development of new metabolic probes that visualize distinct parameters of cell function during disease.

Original language	English (US)
Pages (from-to)	100-105
Number of pages	6
Journal	Current Opinion in Genetics and Development
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.gde.2009.10.008
State	Published - Feb 2010
Externally published	Yes

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1016/j.gde.2009.10.008

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title = "Visualizing cancer and immune cell function with metabolic positron emission tomography",

abstract = "Cancer cells and immune cells modulate their metabolism according to specific needs during cancer progression and immune responses. The ability to measure cellular metabolic function in vivo would enable the evaluation of tumors and their response to therapy and also the effectiveness of cellular immune responses to cancer. Positron emission tomography (PET) is a highly sensitive clinical imaging modality that enables whole-body, quantitative measurements of tissue biochemical function. Here, we review work using PET probes for specific metabolic pathways to measure cell function in cancer and immunity. We focus on the use of probes for glycolysis and nucleoside salvage and then discuss the development of new metabolic probes that visualize distinct parameters of cell function during disease.",

author = "Laing, {Rachel E.} and Evan Nair-Gill and Witte, {Owen N.} and Radu, {Caius G.}",

note = "Funding Information: We acknowledge all colleagues who contributed to the work presented here. We acknowledge Andrew Tran for help with figure preparation and Barbara Anderson for help with manuscript preparation. REL is supported by the Tumor Immunology Training Grant ( 5-T32-CA009120-34 ). ENG is supported by US National Institutes of Health T32 GM08042 UCLA Medical Scientist Training Program and Interdisciplinary Training in Virology and Gene Therapy T32 A1065067 . CGR is supported by National Cancer Institute Grant No. 5U54 CA119347 , In Vivo Cellular and Molecular Imaging Centers (ICMIC) Developmental Project Award NIH P50 CA86306, the CIRM Tools and Technology Grant and the Dana Foundation. ONW is an Investigator of the Howard Hughes Medical Institute. ",

year = "2010",

month = feb,

doi = "10.1016/j.gde.2009.10.008",

language = "English (US)",

volume = "20",

pages = "100--105",

journal = "Current Opinion in Genetics and Development",

issn = "0959-437X",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Visualizing cancer and immune cell function with metabolic positron emission tomography

AU - Laing, Rachel E.

AU - Nair-Gill, Evan

AU - Witte, Owen N.

AU - Radu, Caius G.

N1 - Funding Information: We acknowledge all colleagues who contributed to the work presented here. We acknowledge Andrew Tran for help with figure preparation and Barbara Anderson for help with manuscript preparation. REL is supported by the Tumor Immunology Training Grant ( 5-T32-CA009120-34 ). ENG is supported by US National Institutes of Health T32 GM08042 UCLA Medical Scientist Training Program and Interdisciplinary Training in Virology and Gene Therapy T32 A1065067 . CGR is supported by National Cancer Institute Grant No. 5U54 CA119347 , In Vivo Cellular and Molecular Imaging Centers (ICMIC) Developmental Project Award NIH P50 CA86306, the CIRM Tools and Technology Grant and the Dana Foundation. ONW is an Investigator of the Howard Hughes Medical Institute.

PY - 2010/2

Y1 - 2010/2

N2 - Cancer cells and immune cells modulate their metabolism according to specific needs during cancer progression and immune responses. The ability to measure cellular metabolic function in vivo would enable the evaluation of tumors and their response to therapy and also the effectiveness of cellular immune responses to cancer. Positron emission tomography (PET) is a highly sensitive clinical imaging modality that enables whole-body, quantitative measurements of tissue biochemical function. Here, we review work using PET probes for specific metabolic pathways to measure cell function in cancer and immunity. We focus on the use of probes for glycolysis and nucleoside salvage and then discuss the development of new metabolic probes that visualize distinct parameters of cell function during disease.

AB - Cancer cells and immune cells modulate their metabolism according to specific needs during cancer progression and immune responses. The ability to measure cellular metabolic function in vivo would enable the evaluation of tumors and their response to therapy and also the effectiveness of cellular immune responses to cancer. Positron emission tomography (PET) is a highly sensitive clinical imaging modality that enables whole-body, quantitative measurements of tissue biochemical function. Here, we review work using PET probes for specific metabolic pathways to measure cell function in cancer and immunity. We focus on the use of probes for glycolysis and nucleoside salvage and then discuss the development of new metabolic probes that visualize distinct parameters of cell function during disease.

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Visualizing cancer and immune cell function with metabolic positron emission tomography

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