Visualizing cancer and immune cell function with metabolic positron emission tomography

Rachel E. Laing, Evan Nair-Gill, Owen N. Witte, Caius G. Radu

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Cancer cells and immune cells modulate their metabolism according to specific needs during cancer progression and immune responses. The ability to measure cellular metabolic function in vivo would enable the evaluation of tumors and their response to therapy and also the effectiveness of cellular immune responses to cancer. Positron emission tomography (PET) is a highly sensitive clinical imaging modality that enables whole-body, quantitative measurements of tissue biochemical function. Here, we review work using PET probes for specific metabolic pathways to measure cell function in cancer and immunity. We focus on the use of probes for glycolysis and nucleoside salvage and then discuss the development of new metabolic probes that visualize distinct parameters of cell function during disease.

Original languageEnglish (US)
Pages (from-to)100-105
Number of pages6
JournalCurrent Opinion in Genetics and Development
Volume20
Issue number1
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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