Abstract
Quantifying the amount and defining the location of metal ions in cells and organisms are critical steps in understanding metal homeostasis and how dyshomeostasis causes or is a consequence of disease. A number of recent advances have been made in the development and application of analytical methods to visualize metal ions in biological specimens. Here, we briefly summarize these advances before focusing in more depth on probes for examining transition metals in living cells with high spatial and temporal resolution using fluorescence microscopy. This article is part of a Special Issue entitled: Cell Biology of Metals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1406-1415 |
| Number of pages | 10 |
| Journal | Biochimica et Biophysica Acta - Molecular Cell Research |
| Volume | 1823 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2012 |
Keywords
- Fluorescence imaging
- Fluorescent sensors
- Imaging metal ions in cells
- Metal ion homeostasis
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology
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Dean, K. M., Qin, Y., & Palmer, A. E. (2012). Visualizing metal ions in cells: An overview of analytical techniques, approaches, and probes. Biochimica et Biophysica Acta - Molecular Cell Research, 1823(9), 1406-1415. https://doi.org/10.1016/j.bbamcr.2012.04.001