Abstract
Quantifying the amount and defining the location of metal ions in cells and organisms are critical steps in understanding metal homeostasis and how dyshomeostasis causes or is a consequence of disease. A number of recent advances have been made in the development and application of analytical methods to visualize metal ions in biological specimens. Here, we briefly summarize these advances before focusing in more depth on probes for examining transition metals in living cells with high spatial and temporal resolution using fluorescence microscopy. This article is part of a Special Issue entitled: Cell Biology of Metals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1406-1415 |
| Number of pages | 10 |
| Journal | Biochimica et Biophysica Acta - Molecular Cell Research |
| Volume | 1823 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2012 |
| Externally published | Yes |
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Keywords
- Fluorescence imaging
- Fluorescent sensors
- Imaging metal ions in cells
- Metal ion homeostasis
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology
Cite this
Visualizing metal ions in cells : An overview of analytical techniques, approaches, and probes. / Dean, Kevin M.; Qin, Yan; Palmer, Amy E.
In: Biochimica et Biophysica Acta - Molecular Cell Research, Vol. 1823, No. 9, 01.09.2012, p. 1406-1415.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Visualizing metal ions in cells
T2 - An overview of analytical techniques, approaches, and probes
AU - Dean, Kevin M.
AU - Qin, Yan
AU - Palmer, Amy E.
PY - 2012/9/1
Y1 - 2012/9/1
N2 - Quantifying the amount and defining the location of metal ions in cells and organisms are critical steps in understanding metal homeostasis and how dyshomeostasis causes or is a consequence of disease. A number of recent advances have been made in the development and application of analytical methods to visualize metal ions in biological specimens. Here, we briefly summarize these advances before focusing in more depth on probes for examining transition metals in living cells with high spatial and temporal resolution using fluorescence microscopy. This article is part of a Special Issue entitled: Cell Biology of Metals.
AB - Quantifying the amount and defining the location of metal ions in cells and organisms are critical steps in understanding metal homeostasis and how dyshomeostasis causes or is a consequence of disease. A number of recent advances have been made in the development and application of analytical methods to visualize metal ions in biological specimens. Here, we briefly summarize these advances before focusing in more depth on probes for examining transition metals in living cells with high spatial and temporal resolution using fluorescence microscopy. This article is part of a Special Issue entitled: Cell Biology of Metals.
KW - Fluorescence imaging
KW - Fluorescent sensors
KW - Imaging metal ions in cells
KW - Metal ion homeostasis
UR - http://www.scopus.com/inward/record.url?scp=84864310728&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864310728&partnerID=8YFLogxK
U2 - 10.1016/j.bbamcr.2012.04.001
DO - 10.1016/j.bbamcr.2012.04.001
M3 - Review article
C2 - 22521452
AN - SCOPUS:84864310728
VL - 1823
SP - 1406
EP - 1415
JO - Biochimica et Biophysica Acta - Molecular Cell Research
JF - Biochimica et Biophysica Acta - Molecular Cell Research
SN - 0167-4889
IS - 9
ER -