Vitamin D and cardiovascular disease

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Vitamin D is best known for its influence on skeletal health. There is growing recognition, however, that vitamin D has nonskeletal actions, which could have important implications for understanding the consequences of vitamin D deficiency. In epidemiologic studies, vitamin D deficiency has been consistently associated with an increased risk for cardiovascular disease and hypertension. Disruption of vitamin D signaling in animal models promotes hypertension, cardiac hypertrophy, and atherosclerosis. This evidence has led to the initiation of prospective randomized trials of vitamin D supplementation in individuals at risk for cardiovascular disease. The results of these trials should help to guide strategies for screening and management of vitamin D deficiency in the clinic and at the population level.

Original languageEnglish (US)
Pages (from-to)261-272
Number of pages12
JournalAnnual review of medicine
Volume67
DOIs
StatePublished - Jan 14 2016
Externally publishedYes

Keywords

  • Cardiovascular disease
  • Prevention
  • Vitamin D

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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