Vitamin D and cardiovascular risk

Shweta R. Motiwala, Thomas J. Wang

Research output: Contribution to journalArticle

Abstract

Vitamin D deficiency is a common condition that has well-documented effects on musculoskeletal health. A growing body of literature has related vitamin D deficiency to other chronic disorders, including cardiovascular disease. Several plausible biological mechanisms have been postulated to explain this association, including the effect of poor vitamin D status on intermediate risk factors (eg, hypertension and diabetes), neurohormonal activation, inflammation, and cardiac remodeling. These mechanisms have been explored in experimental and animal studies, as well as several small interventional studies. The results of the controlled trials have not been conclusive to date. In this review, we summarize the existing studies investigating the effects of vitamin D on cardiovascular health, and propose that additional well-designed, prospective, randomized controlled trials are necessary to delineate the appropriate role of vitamin D supplementation in reducing the burden of cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)209-218
Number of pages10
JournalCurrent hypertension reports
Volume14
Issue number3
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

Keywords

  • Blood pressure
  • Cardiovascular disease
  • Cardiovascular risk
  • Coronary artery disease
  • Diabetes mellitus
  • Hypertension
  • Vitamin D

ASJC Scopus subject areas

  • Internal Medicine

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