Vitamin D and chronic lung disease: A review of molecular mechanisms and clinical studies

James D. Finklea, Ruth E. Grossmann, Vin Tangpricha

Research output: Contribution to journalReview article

78 Scopus citations

Abstract

Vitamin D is classically recognized for its role in calcium homeostasis and skeletal metabolism. Over the last few decades, vitamin D deficiency has increased in prevalence in adults and children. Potential extraskeletal effects of vitamin D have been under investigation for several diseases. Several cross-sectional studies have associated lower vitamin D status with decreased lung function. This finding has prompted investigators to examine the association of vitamin D deficiency with several chronic lung diseases. One major focus has been the link between maternal vitamin D status and childhood asthma. Vitamin D deficiency has also been associated with increased risk of respiratory infection from influenza A and Mycobacterium tuberculosis. Other chronic respiratory diseases associated with vitamin D deficiency include cystic fibrosis, interstitial lung disease, and chronic obstructive pulmonary disease. This review will examine the current clinical literature and potential mechanisms of vitamin D in various pulmonary diseases.

Original languageEnglish (US)
Pages (from-to)244-253
Number of pages10
JournalAdvances in Nutrition
Volume2
Issue number3
DOIs
StatePublished - May 2011

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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