Vitamin D and Heart Failure

D. Marshall Brinkley, Omair M. Ali, Sandip K. Zalawadiya, Thomas J. Wang

Research output: Contribution to journalReview article


Purpose: Vitamin D is principally known for its role in calcium homeostasis, but preclinical studies implicate multiple pathways through which vitamin D may affect cardiovascular function and influence risk for heart failure. Many adults with cardiovascular disease have low vitamin D status, making it a potential therapeutic target. We review the rationale and potential role of vitamin D supplementation in the prevention and treatment of chronic heart failure. Recent Findings.: Substantial observational evidence has associated low vitamin D status with the risk of heart failure, ventricular remodeling, and clinical outcomes in heart failure, including mortality. However, trials assessing the influence of vitamin D supplementation on surrogate markers and clinical outcomes in heart failure have generally been small and inconclusive. Summary: There are insufficient data to recommend routine assessment or supplementation of vitamin D for the prevention or treatment of chronic heart failure. Prospective trials powered for clinical outcomes are warranted.

Original languageEnglish (US)
Pages (from-to)410-420
Number of pages11
JournalCurrent heart failure reports
Issue number5
StatePublished - Oct 1 2017
Externally publishedYes


  • Cardiovascular disease
  • Heart failure
  • Outcomes
  • Vitamin D

ASJC Scopus subject areas

  • Emergency Medicine
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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  • Cite this

    Marshall Brinkley, D., Ali, O. M., Zalawadiya, S. K., & Wang, T. J. (2017). Vitamin D and Heart Failure. Current heart failure reports, 14(5), 410-420.