Vitamin D status and concomitant autoimmunity in celiac disease

Anna Tavakkoli, Daniel Digiacomo, Peter H. Green, Benjamin Lebwohl

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

GOALS:: To determine whether patients with celiac disease (CD) and low vitamin D levels also have a higher prevalence of other autoimmune diseases (AD) as compared with patients with normal vitamin D levels. BACKGROUND:: Patients with CD carry a higher risk of other autoimmune disorders. Because of its immunoregulatory properties, vitamin D deficiency has been proposed in the pathogenesis of a variety of AD. Whether low vitamin D levels in patients with CD can predict concomitant AD is unknown. STUDY:: A retrospective cross-sectional study of 530 adult patients with CD and a 25-hydroxyvitamin D level on record at Columbia University Medical Center. RESULTS:: One hundred thirty-three patients (25%) had vitamin D deficiency. The prevalence of AD was similar among those with normal vitamin D levels (11%), insufficiency (9%), and deficiency (12%, P=0.66). On multivariate analysis, adjusting for age of CD diagnosis and sex, vitamin D deficiency was not associated with AD (odds ratio, 1.35; 95% confidence interval, 0.62-2.95). The risk of psoriasis was higher in patients with vitamin D deficiency (7% vs. 3%, P=0.04). Vitamin D deficiency was more common in those who presented with anemia (39%) than in those who did not (23% P=0.002). CONCLUSIONS:: Vitamin D deficiency in CD is common but does not predict AD. The risk of psoriasis is increased in vitamin D-deficient CD patients. Assessment of vitamin D seems to be a high-yield practice, especially in those CD patients who present with anemia.

Original languageEnglish (US)
Pages (from-to)515-519
Number of pages5
JournalJournal of Clinical Gastroenterology
Volume47
Issue number6
DOIs
StatePublished - Jul 1 2013
Externally publishedYes

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Celiac Disease
Autoimmunity
Vitamin D
Vitamin D Deficiency
Autoimmune Diseases
Psoriasis
Anemia
Multivariate Analysis
Cross-Sectional Studies
Odds Ratio
Confidence Intervals

Keywords

  • Autoimmune disease
  • Celiac disease
  • Vitamin D

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Vitamin D status and concomitant autoimmunity in celiac disease. / Tavakkoli, Anna; Digiacomo, Daniel; Green, Peter H.; Lebwohl, Benjamin.

In: Journal of Clinical Gastroenterology, Vol. 47, No. 6, 01.07.2013, p. 515-519.

Research output: Contribution to journalArticle

Tavakkoli, Anna ; Digiacomo, Daniel ; Green, Peter H. ; Lebwohl, Benjamin. / Vitamin D status and concomitant autoimmunity in celiac disease. In: Journal of Clinical Gastroenterology. 2013 ; Vol. 47, No. 6. pp. 515-519.
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