Vitamin D status is a determinant of atorvastatin effect on carotid intima medial thickening progression rate in children with lupus: An Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) substudy

Angela Byun Robinson, Vin Tangpricha, Eric Yow, Reut Gurion, Laura E. Schanberg, Grace A. McComsey, Stacy Ardoin, Esi Morgan Dewitt, C. Egla Rabinovich, Janet Ellis, Kelly Mieszkalski, Janet Wootton, Peter Chira, Joyce Hsu, Tzielan Lee, Christy Sandborg, Jan Perea, Beth Gottlieb, Patricia Irigoyen, Jennifer LuftigShaz Siddiqi, Zhen Ni, Marilynn Orlando, Eileen Pagano, Andrew Eichenfield, Lisa Imundo, Deborah Levy, Philip Kahn, Candido Batres, Digna Cabral, Kathleen A. Haines, Yukiko Kimura, Suzanne C. Li, Jennifer Weiss, Mary Ellen Riordan, Beena Vaidya, Emily Von Scheven, Michelle Mietus-Snyder, Earl Silverman, Lawrence Ng, Suzanne Bowyer, Susan Ballinger, Thomas Klausmeier, Debra Hinchman, Andrea Hudgins, Marilynn Punaro, Shirley Henry, Shuzen Zhang, Nora G. Singer, Elizabeth B. Brooks, Stacy Miner, Nancy Szabo, Lisabeth Scalzi, David Sherry, Libby Dorfeld, Sarajane Wilson, Jenna Tress, Deborah McCurdy, Tatiana Hernandez, Jyotsna Vitale, Marisa Klein-Gitelman, Angela Kress, Nicole Lowe, Falguni Patel, Carol Wallace, Stephanie Hamilton, Richard Silver, Katie Caldwell, Diane Kamen, Linda Wagner-Weiner, Becky Puplava, Atanas Lonchev, Gloria Higgins, Monica Bacani, Hermine Brunner, Cynthia Rutherford, Jamie Meyers-Eaton, Shannen Nelson, Alexei Grom, Larry Jung, Teresa Conway, Lacey Frank, Lori Kuss, Jenny Soep, Hazel Senz, Ann Reed, Thomas Mason, Jane Jaquith, Diana E. Paepke-Tollefsrud

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: Epidemiological associations suggest that vitamin D status may play a role in inflammation and progression of atherosclerosis. Using frozen serum, carotid intima medial thickness (CIMT) measurements and other existing data from the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, we assessed interactions between serum 25-hydroxyvitamin D (25(OH)D), atorvastatin randomisation and CIMT progression rate. Methods: Participants in the 3-year APPLE trial were randomised to placebo or atorvastatin and CIMT progression rate was measured. Baseline frozen serum was used to measure 25(OH)D concentrations. Mixed effect longitudinal models for CIMT progression at 3 years were used to evaluate interaction between vitamin D deficiency (serum 25(OH)D

Original languageEnglish (US)
Article numbere000037
JournalLupus Science and Medicine
Volume1
Issue number1
DOIs
StatePublished - Jun 1 2014

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Vitamin D
Atherosclerosis
Pediatrics
Serum
Vitamin D Deficiency
Random Allocation
Placebos
Inflammation
Atorvastatin Calcium

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology

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Vitamin D status is a determinant of atorvastatin effect on carotid intima medial thickening progression rate in children with lupus : An Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) substudy. / Robinson, Angela Byun; Tangpricha, Vin; Yow, Eric; Gurion, Reut; Schanberg, Laura E.; McComsey, Grace A.; Ardoin, Stacy; Dewitt, Esi Morgan; Rabinovich, C. Egla; Ellis, Janet; Mieszkalski, Kelly; Wootton, Janet; Chira, Peter; Hsu, Joyce; Lee, Tzielan; Sandborg, Christy; Perea, Jan; Gottlieb, Beth; Irigoyen, Patricia; Luftig, Jennifer; Siddiqi, Shaz; Ni, Zhen; Orlando, Marilynn; Pagano, Eileen; Eichenfield, Andrew; Imundo, Lisa; Levy, Deborah; Kahn, Philip; Batres, Candido; Cabral, Digna; Haines, Kathleen A.; Kimura, Yukiko; Li, Suzanne C.; Weiss, Jennifer; Riordan, Mary Ellen; Vaidya, Beena; Von Scheven, Emily; Mietus-Snyder, Michelle; Silverman, Earl; Ng, Lawrence; Bowyer, Suzanne; Ballinger, Susan; Klausmeier, Thomas; Hinchman, Debra; Hudgins, Andrea; Punaro, Marilynn; Henry, Shirley; Zhang, Shuzen; Singer, Nora G.; Brooks, Elizabeth B.; Miner, Stacy; Szabo, Nancy; Scalzi, Lisabeth; Sherry, David; Dorfeld, Libby; Wilson, Sarajane; Tress, Jenna; McCurdy, Deborah; Hernandez, Tatiana; Vitale, Jyotsna; Klein-Gitelman, Marisa; Kress, Angela; Lowe, Nicole; Patel, Falguni; Wallace, Carol; Hamilton, Stephanie; Silver, Richard; Caldwell, Katie; Kamen, Diane; Wagner-Weiner, Linda; Puplava, Becky; Lonchev, Atanas; Higgins, Gloria; Bacani, Monica; Brunner, Hermine; Rutherford, Cynthia; Meyers-Eaton, Jamie; Nelson, Shannen; Grom, Alexei; Jung, Larry; Conway, Teresa; Frank, Lacey; Kuss, Lori; Soep, Jenny; Senz, Hazel; Reed, Ann; Mason, Thomas; Jaquith, Jane; Paepke-Tollefsrud, Diana E.

In: Lupus Science and Medicine, Vol. 1, No. 1, e000037, 01.06.2014.

Research output: Contribution to journalArticle

Robinson, AB, Tangpricha, V, Yow, E, Gurion, R, Schanberg, LE, McComsey, GA, Ardoin, S, Dewitt, EM, Rabinovich, CE, Ellis, J, Mieszkalski, K, Wootton, J, Chira, P, Hsu, J, Lee, T, Sandborg, C, Perea, J, Gottlieb, B, Irigoyen, P, Luftig, J, Siddiqi, S, Ni, Z, Orlando, M, Pagano, E, Eichenfield, A, Imundo, L, Levy, D, Kahn, P, Batres, C, Cabral, D, Haines, KA, Kimura, Y, Li, SC, Weiss, J, Riordan, ME, Vaidya, B, Von Scheven, E, Mietus-Snyder, M, Silverman, E, Ng, L, Bowyer, S, Ballinger, S, Klausmeier, T, Hinchman, D, Hudgins, A, Punaro, M, Henry, S, Zhang, S, Singer, NG, Brooks, EB, Miner, S, Szabo, N, Scalzi, L, Sherry, D, Dorfeld, L, Wilson, S, Tress, J, McCurdy, D, Hernandez, T, Vitale, J, Klein-Gitelman, M, Kress, A, Lowe, N, Patel, F, Wallace, C, Hamilton, S, Silver, R, Caldwell, K, Kamen, D, Wagner-Weiner, L, Puplava, B, Lonchev, A, Higgins, G, Bacani, M, Brunner, H, Rutherford, C, Meyers-Eaton, J, Nelson, S, Grom, A, Jung, L, Conway, T, Frank, L, Kuss, L, Soep, J, Senz, H, Reed, A, Mason, T, Jaquith, J & Paepke-Tollefsrud, DE 2014, 'Vitamin D status is a determinant of atorvastatin effect on carotid intima medial thickening progression rate in children with lupus: An Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) substudy', Lupus Science and Medicine, vol. 1, no. 1, e000037. https://doi.org/10.1136/lupus-2014-000037
Robinson, Angela Byun ; Tangpricha, Vin ; Yow, Eric ; Gurion, Reut ; Schanberg, Laura E. ; McComsey, Grace A. ; Ardoin, Stacy ; Dewitt, Esi Morgan ; Rabinovich, C. Egla ; Ellis, Janet ; Mieszkalski, Kelly ; Wootton, Janet ; Chira, Peter ; Hsu, Joyce ; Lee, Tzielan ; Sandborg, Christy ; Perea, Jan ; Gottlieb, Beth ; Irigoyen, Patricia ; Luftig, Jennifer ; Siddiqi, Shaz ; Ni, Zhen ; Orlando, Marilynn ; Pagano, Eileen ; Eichenfield, Andrew ; Imundo, Lisa ; Levy, Deborah ; Kahn, Philip ; Batres, Candido ; Cabral, Digna ; Haines, Kathleen A. ; Kimura, Yukiko ; Li, Suzanne C. ; Weiss, Jennifer ; Riordan, Mary Ellen ; Vaidya, Beena ; Von Scheven, Emily ; Mietus-Snyder, Michelle ; Silverman, Earl ; Ng, Lawrence ; Bowyer, Suzanne ; Ballinger, Susan ; Klausmeier, Thomas ; Hinchman, Debra ; Hudgins, Andrea ; Punaro, Marilynn ; Henry, Shirley ; Zhang, Shuzen ; Singer, Nora G. ; Brooks, Elizabeth B. ; Miner, Stacy ; Szabo, Nancy ; Scalzi, Lisabeth ; Sherry, David ; Dorfeld, Libby ; Wilson, Sarajane ; Tress, Jenna ; McCurdy, Deborah ; Hernandez, Tatiana ; Vitale, Jyotsna ; Klein-Gitelman, Marisa ; Kress, Angela ; Lowe, Nicole ; Patel, Falguni ; Wallace, Carol ; Hamilton, Stephanie ; Silver, Richard ; Caldwell, Katie ; Kamen, Diane ; Wagner-Weiner, Linda ; Puplava, Becky ; Lonchev, Atanas ; Higgins, Gloria ; Bacani, Monica ; Brunner, Hermine ; Rutherford, Cynthia ; Meyers-Eaton, Jamie ; Nelson, Shannen ; Grom, Alexei ; Jung, Larry ; Conway, Teresa ; Frank, Lacey ; Kuss, Lori ; Soep, Jenny ; Senz, Hazel ; Reed, Ann ; Mason, Thomas ; Jaquith, Jane ; Paepke-Tollefsrud, Diana E. / Vitamin D status is a determinant of atorvastatin effect on carotid intima medial thickening progression rate in children with lupus : An Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) substudy. In: Lupus Science and Medicine. 2014 ; Vol. 1, No. 1.
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title = "Vitamin D status is a determinant of atorvastatin effect on carotid intima medial thickening progression rate in children with lupus: An Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) substudy",
abstract = "Objective: Epidemiological associations suggest that vitamin D status may play a role in inflammation and progression of atherosclerosis. Using frozen serum, carotid intima medial thickness (CIMT) measurements and other existing data from the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, we assessed interactions between serum 25-hydroxyvitamin D (25(OH)D), atorvastatin randomisation and CIMT progression rate. Methods: Participants in the 3-year APPLE trial were randomised to placebo or atorvastatin and CIMT progression rate was measured. Baseline frozen serum was used to measure 25(OH)D concentrations. Mixed effect longitudinal models for CIMT progression at 3 years were used to evaluate interaction between vitamin D deficiency (serum 25(OH)D",
author = "Robinson, {Angela Byun} and Vin Tangpricha and Eric Yow and Reut Gurion and Schanberg, {Laura E.} and McComsey, {Grace A.} and Stacy Ardoin and Dewitt, {Esi Morgan} and Rabinovich, {C. Egla} and Janet Ellis and Kelly Mieszkalski and Janet Wootton and Peter Chira and Joyce Hsu and Tzielan Lee and Christy Sandborg and Jan Perea and Beth Gottlieb and Patricia Irigoyen and Jennifer Luftig and Shaz Siddiqi and Zhen Ni and Marilynn Orlando and Eileen Pagano and Andrew Eichenfield and Lisa Imundo and Deborah Levy and Philip Kahn and Candido Batres and Digna Cabral and Haines, {Kathleen A.} and Yukiko Kimura and Li, {Suzanne C.} and Jennifer Weiss and Riordan, {Mary Ellen} and Beena Vaidya and {Von Scheven}, Emily and Michelle Mietus-Snyder and Earl Silverman and Lawrence Ng and Suzanne Bowyer and Susan Ballinger and Thomas Klausmeier and Debra Hinchman and Andrea Hudgins and Marilynn Punaro and Shirley Henry and Shuzen Zhang and Singer, {Nora G.} and Brooks, {Elizabeth B.} and Stacy Miner and Nancy Szabo and Lisabeth Scalzi and David Sherry and Libby Dorfeld and Sarajane Wilson and Jenna Tress and Deborah McCurdy and Tatiana Hernandez and Jyotsna Vitale and Marisa Klein-Gitelman and Angela Kress and Nicole Lowe and Falguni Patel and Carol Wallace and Stephanie Hamilton and Richard Silver and Katie Caldwell and Diane Kamen and Linda Wagner-Weiner and Becky Puplava and Atanas Lonchev and Gloria Higgins and Monica Bacani and Hermine Brunner and Cynthia Rutherford and Jamie Meyers-Eaton and Shannen Nelson and Alexei Grom and Larry Jung and Teresa Conway and Lacey Frank and Lori Kuss and Jenny Soep and Hazel Senz and Ann Reed and Thomas Mason and Jane Jaquith and Paepke-Tollefsrud, {Diana E.}",
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T1 - Vitamin D status is a determinant of atorvastatin effect on carotid intima medial thickening progression rate in children with lupus

T2 - An Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) substudy

AU - Robinson, Angela Byun

AU - Tangpricha, Vin

AU - Yow, Eric

AU - Gurion, Reut

AU - Schanberg, Laura E.

AU - McComsey, Grace A.

AU - Ardoin, Stacy

AU - Dewitt, Esi Morgan

AU - Rabinovich, C. Egla

AU - Ellis, Janet

AU - Mieszkalski, Kelly

AU - Wootton, Janet

AU - Chira, Peter

AU - Hsu, Joyce

AU - Lee, Tzielan

AU - Sandborg, Christy

AU - Perea, Jan

AU - Gottlieb, Beth

AU - Irigoyen, Patricia

AU - Luftig, Jennifer

AU - Siddiqi, Shaz

AU - Ni, Zhen

AU - Orlando, Marilynn

AU - Pagano, Eileen

AU - Eichenfield, Andrew

AU - Imundo, Lisa

AU - Levy, Deborah

AU - Kahn, Philip

AU - Batres, Candido

AU - Cabral, Digna

AU - Haines, Kathleen A.

AU - Kimura, Yukiko

AU - Li, Suzanne C.

AU - Weiss, Jennifer

AU - Riordan, Mary Ellen

AU - Vaidya, Beena

AU - Von Scheven, Emily

AU - Mietus-Snyder, Michelle

AU - Silverman, Earl

AU - Ng, Lawrence

AU - Bowyer, Suzanne

AU - Ballinger, Susan

AU - Klausmeier, Thomas

AU - Hinchman, Debra

AU - Hudgins, Andrea

AU - Punaro, Marilynn

AU - Henry, Shirley

AU - Zhang, Shuzen

AU - Singer, Nora G.

AU - Brooks, Elizabeth B.

AU - Miner, Stacy

AU - Szabo, Nancy

AU - Scalzi, Lisabeth

AU - Sherry, David

AU - Dorfeld, Libby

AU - Wilson, Sarajane

AU - Tress, Jenna

AU - McCurdy, Deborah

AU - Hernandez, Tatiana

AU - Vitale, Jyotsna

AU - Klein-Gitelman, Marisa

AU - Kress, Angela

AU - Lowe, Nicole

AU - Patel, Falguni

AU - Wallace, Carol

AU - Hamilton, Stephanie

AU - Silver, Richard

AU - Caldwell, Katie

AU - Kamen, Diane

AU - Wagner-Weiner, Linda

AU - Puplava, Becky

AU - Lonchev, Atanas

AU - Higgins, Gloria

AU - Bacani, Monica

AU - Brunner, Hermine

AU - Rutherford, Cynthia

AU - Meyers-Eaton, Jamie

AU - Nelson, Shannen

AU - Grom, Alexei

AU - Jung, Larry

AU - Conway, Teresa

AU - Frank, Lacey

AU - Kuss, Lori

AU - Soep, Jenny

AU - Senz, Hazel

AU - Reed, Ann

AU - Mason, Thomas

AU - Jaquith, Jane

AU - Paepke-Tollefsrud, Diana E.

PY - 2014/6/1

Y1 - 2014/6/1

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AB - Objective: Epidemiological associations suggest that vitamin D status may play a role in inflammation and progression of atherosclerosis. Using frozen serum, carotid intima medial thickness (CIMT) measurements and other existing data from the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, we assessed interactions between serum 25-hydroxyvitamin D (25(OH)D), atorvastatin randomisation and CIMT progression rate. Methods: Participants in the 3-year APPLE trial were randomised to placebo or atorvastatin and CIMT progression rate was measured. Baseline frozen serum was used to measure 25(OH)D concentrations. Mixed effect longitudinal models for CIMT progression at 3 years were used to evaluate interaction between vitamin D deficiency (serum 25(OH)D

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U2 - 10.1136/lupus-2014-000037

DO - 10.1136/lupus-2014-000037

M3 - Article

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AN - SCOPUS:84930194157

VL - 1

JO - Lupus Science and Medicine

JF - Lupus Science and Medicine

SN - 2053-8790

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