Vitamin E Deficiency with Normal Serum Vitamin E Concentrations in Children with Chronic Cholestasis

R. J. Sokol, J. E. Heubi, S. T. Iannaccone, K. E. Bove, W. F. Balistreri

Research output: Contribution to journalArticlepeer-review

147 Scopus citations

Abstract

We studied serum vitamin E levels and the ratio of serum vitamin E to serum lipid levels in 11 children with chronic cholestasis complicated by vitamin E deficiency, as defined by characteristic neurologic signs or sural-nerve histopathology in addition to impaired intestinal absorption of vitamin E. Eight of the children had low levels of serum vitamin E, as well as low ratios of serum vitamin E to total lipids and to cholesterol. However, three patients had normal serum vitamin E levels but low ratios of serum vitamin E to total lipids (two of the three had normal ratios of vitamin E to cholesterol). In four patients who were not vitamin E-deficient, all three values were normal. We conclude that vitamin E deficiency may exist in a child with a normal serum vitamin E concentration and that the ratio of serum vitamin E to total serum lipids is the most reliable biochemical index of vitamin E status during chronic childhood cholestasis. (N Engl J Med 1984; 310: 1209–12.).

Original languageEnglish (US)
Pages (from-to)1209-1212
Number of pages4
JournalNew England Journal of Medicine
Volume310
Issue number19
DOIs
StatePublished - May 10 1984

ASJC Scopus subject areas

  • Medicine(all)

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