VMN lesion deficits in lordosis: Partial reversal with pergolide mesylate

Dana Mathews, Susan B. Greene, Eileen M. Hollingsworth

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Bilateral lesions of the VMN virtually eliminate estrogen-progesterone stimulated lordosis in the spayed female rat. The present paper demonstrates that some recovery in lordosis is possible following treatment with pergolide mesylate, a potent long acting dopamine agonist. Chronic administration of pergolide mesylate in combination with estrogen and progesterone resulted in significant recovery of lordosis in VMN lesioned female rats. The magnitude of recovery was related to the duration and/or dose of pergolide.

Original languageEnglish (US)
Pages (from-to)745-748
Number of pages4
JournalPhysiology and Behavior
Volume31
Issue number6
DOIs
StatePublished - Dec 1983
Externally publishedYes

Keywords

  • Lordosis behavior
  • Pergolide mesylate
  • VMN lesions

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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