Volume catheter parallel conductance varies between end-systole and end-diastole

Chia Ling Wei, Jonathan W. Valvano, Marc D. Feldman, Matthias Nahrendorf, Ronald M Peshock, John A. Pearce

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

In order for the conductance catheter system to accurately measure instantaneous cardiac blood volume, it is necessary to determine and remove the contribution from parallel myocardial tissue. In previous studies, the myocardium has been treated as either purely resistive or purely capacitive when developing methods to estimate the myocardial contribution. We propose that both the capacitive and the resistive properties of the myocardium are substantial, and neither should be ignored. Hence, the measured result should be labeled admittance rather than conductance. We have measured the admittance (magnitude and phase angle) of the left ventricle in the mouse, and have shown that it is measurable and increases with frequency. Further, this more accurate technique suggests that the myocardial contribution to measured admittance varies between end-systole and end-diastole, contrary to previous literature. We have tested these hypotheses both with numerical finite-element models for a mouse left ventricle constructed from magnetic resonance imaging images, and with in vivo admittance measurements in the murine left ventricle. Finally, we propose a new method to determine the instantaneous myocardial contribution to the measured left ventricular admittance that does not require saline injection or other intervention to calibrate.

Original languageEnglish (US)
Pages (from-to)1480-1489
Number of pages10
JournalIEEE Transactions on Biomedical Engineering
Volume54
Issue number8
DOIs
StatePublished - Aug 1 2007

Keywords

  • Admittance
  • Conductance catheter
  • Finite-element model
  • Parallel conductance
  • Parallel myocardial admittance
  • Phase angle measurement
  • Ventricular volume

ASJC Scopus subject areas

  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Volume catheter parallel conductance varies between end-systole and end-diastole'. Together they form a unique fingerprint.

  • Cite this